Neurosurgery Watch

Stay up to date with the latest clinical findings in Neurosurgery Watch. Each month, our panel identifies and summarizes key points of selected significant papers from over 50 journals. We emphasize the most significant findings that potentially change clinical management or treatment of neurological diseases.

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John S. Kuo, MD PhD FACS
Madison, Wisconsin
Co-Editor
Robert Starke, MD MSc
Miami, Florida 
Co-Editor
Search Neurosurgery Watch
CV

Stenting vs. medical treatment in patients with symptomatic vertebral artery stenosis: a randomized open-label phase 2 trial

October 5, 2015
Cerebrovascular
By: 
Alexander A. Khalessi, MD
Source: 
Pubmed

The VAST trial randomized patients suffering a minor stroke or transient ischemic attack due to >50% vertebral artery stenosis to medical therapy versus vertebral artery stenting. It enrolled 115 patients and was halted prematurely due to insufficient funding.  The primary...

PE

Continuous EEG in subclinical seizures in moderate to severe pediatric TBI

August 31, 2015
Pediatrics
By: 
Brandon G. Rocque, MD, MS
Source: 
JNS Peds

The impact of sub-clinical seizures on outcomes and management of adult head injury have been studied extensively. In this study, children with moderate or severe TBI (GCS 3-12), admitted to Children’s Hospital of Colorado, underwent at least 48 hours of...

SP

Steroid Use After Anterior Cervical Surgery Reduces Early Postoperative Dysphagia

August 31, 2015
Spine
By: 
H. Francis Farhadi, MD PhD
Source: 
Journal of Neurosurgery Reference

Steroid administration has been suggested as a possible treatment for post-operative dysphagia, which is a common early adverse event following anterior cervical surgery. Patients (N=112) were randomized in a 1:1 ratio to receive saline or dexamethasone with clinical and radiological...

SF

Lumboperitoneal shunts are safe and effective for normal pressure hydrocephalus

August 31, 2015
Stereotactic & Functional
By: 
Jennifer A Sweet, MD
Johathan P Miller, MD
Source: 
The Lancet Neurology

In a multi-center, randomized trial, the SINPHONI-2 investigators evaluated lumboperitoneal shunts for the treatment of idiopathic NPH, in contrast to the more common practice of using ventriculoperitoneal shunts. Patients (N=93, 60-85 years) with idiopathic NPH from 20 neurological centers in...

TU

Genomic Analysis Identifies New Prognostic Molecular Subtypes of Diffuse Lower-Grade Gliomas

July 30, 2015
Tumor
By: 
Nader Sanai, MD
Source: 
NEJM

The Cancer Genome Atlas Research Network characterized low-grade gliomas through a genome-wide analysis of 293 previously-untreated adult lower-grade glioma: oligodendrogliomas (n=116), astrocytomas (n=100), and oligoastrocytomas (n=77).  Overall, data from DNA copy number, RNA, and DNA methylation status demonstrated three distinct...

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