Neurosurgery Watch

Stay up to date with the latest clinical findings in Neurosurgery Watch. Each month, our panel identifies and summarizes key points of selected significant papers from over 50 journals. We emphasize the most significant findings that potentially change clinical management or treatment of neurological diseases.

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John S. Kuo, MD PhD FACS
Austin, Texas
Co-Editor
Robert Starke, MD MSc
Miami, Florida 
Co-Editor
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Stereotactic radiosurgery alone for patients with up to 10 brain metastases

April 30, 2014
Stereotactic & Functional, Tumor
By: 
Clark C. Chen, MD PhD
Source: 
Lancet Oncology

The role of stereotactic radiosurgery (SRS) for patients with multiple metastases remains uncertain.  A prospective observational study published in Lancet Oncology evaluates the use of SRS without addition of whole brain irradiation on survival for 1194 patients (KPS>70) with 1-10...

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Circumferential thoracolumbar fracture stabilization is safe, with high fusion and stabilization rates

April 30, 2014
Spine
By: 
S. R. Manoharan, MBBS
H. Francis Farhadi, MD PhD
Source: 
Journal of Neurosurgery: Spine

The optimal management of thoracolumbar fractures, with respect to safety, fusion, and clinical outcomes remains uncertain and requires more comprehensive analysis of long-term outcomes. Schnake et al. report their prospective results of circumferential stabilization (posterior stabilization followed by corpectomy and...

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Two Phase III trials do not show improved GBM survival with addition of bevacizumab

March 29, 2014
Tumor
By: 
Nader Sanai, MD

The New England Journal of Medicine (Feb ‘14) reported results from two randomized, double-blind, placebo-controlled Phase III trials testing addition of bevacizumab (BEV) to standard radiation + temozolomide therapy for newly-diagnosed glioblastoma (GBM): Radiation Therapy Oncology Group 0825 and ‘Avastin...

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“ReCCLAIM I”: endovascular reperfusion and hypothermia for severe ischemic stroke

March 29, 2014
Cerebrovascular
By: 
Michelle J. Smith, MD
Source: 
J NeuroIntervent

Horn et al. report a prospective Phase I trial to assess hypothermia in severe cerebral infarction patients treated with mechanical thrombectomy. Although preclinical studies showed improved outcomes with hypothermia, clinical studies performed on a heterogeneous patient population failed to show...

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Fatal Intracerebral Hemorrhage After Pipeline Embolization of Aneurysm: Histopathological Analysis

February 28, 2014
Cerebrovascular
By: 
Stacey Quintero Wolfe, MD
Source: 
Journal of Neurosurgery

Delayed ipsilateral intraparenchymal hemorrhage following aneurysm treatment with the Pipeline Embolization Device has been observed in multiple studies without a clear etiology. This important study demonstrates convincing histopathological evidence of foreign material occluding small vessels within the hemorrhagic area in...

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