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  • Patient-Specific Cerebral Regional Blood Flow Model Using Quantitative MR Angiography to Predict Stump Pressure

    Final Number:

    Daniel Li; Meide Zhao PhD; Sepideh Amin-Hanjani MD, FACS, FAHA; Robert Kufahl; Xinjian Du MD MPH; Victor Allyn Aletich; Ali Alaraj MD; Jianmin Li PhD; Fady T. Charbel MD

    Study Design:
    Clinical trial

    Subject Category:
    Basic Science

    Meeting: AANS/CNS Cerebrovascular Section 2018 Annual Meeting


    Stump pressure (SP) plays an important role in clinical decision making and surgical management relating to planned cerebral vessel occlusion. The goal of this work is to propose a new patient specific, regional cerebral blood flow model to predict SP noninvasively.


    A new patient-specific cerebral regional blood flow model using quantitative MR Angiography (qMRA) was developed to predict the SPs for patients undergoing balloon test occlusion (BTO). This new model is a one-dimensional regional flow model at patient baseline and with internal carotid artery (ICA) occlusion. The baseline model involves calculating the regional blood flows by vessel flow measurements from qMRA, and utilizing peripheral regional resistances. The regional flow model based on ICA occlusion computes the new blood flows and pressures using the simulated occlusion of the ICA while keeping all peripheral regional resistances the same baseline. SPs calculated using the regional flow model with ICA occlusion were compared against the actual SP measurements during BTOs.


    The proposed model was applied to four patients with ICA aneurysms, two of whom passed and two of whom failed BTO. The predicted SP using aortic pressure measurement resulted in -5%, -11%, 3% and 7% error when compared to clinical measurements. The predicted SP using cuff pressure resulted in -6%, -14%, 2% and 6% error when compared to clinical measurements.


    The proposed model using qMRA data and cuff pressure can be used to predict SP with acceptable error for patients who have undergone BTO.

    Patient Care:

    The need to conduct invasive measurements such as balloon occlusion testing to guide clinical decision-making may be reduced with advanced cerebrovascular modeling, limiting discomfort to the patient.

    Learning Objectives:

    By the conclusion of this sessions, participants should be able to better appreciate the use of quantitative MR Angiography to predict stump pressures to ultimately reduce the need for invasive measurements


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