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  • Tumor to Cerebellar Peduncle T2-Weighted Imaging Intensity Ratio Fails to Predict Pituitary Adenoma Consistency

    Final Number:
    1548

    Authors:
    Panagiotis Mastorakos MD; Gautam U. Mehta MD; Ajay Chatrath BS; Shayan Moosa BA; John Jane, Jr

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: The consistency of pituitary macroadenomas affects the complexity of surgical resection. On T2-weighted (T2W) imaging, the intensity ratio of the tumor to the cerebellar peduncle (tumor to cerebellar peduncle T2-weighted imaging intensity; TCTI ratio) correlates with meningioma consistency. We aimed to determine the correlation of this radiographic finding with pituitary macroadenoma consistency and determine whether it can be used for preoperative planning.

    Methods: We performed a retrospective evaluation of 196 patients with macroadenomas who underwent endoscopic transsphenoidal resection from January 2012 to June 2017. Macroadenoma consistency was determined by one senior neurosurgeon at the time of surgery. Axial and coronal T2W MRI images were evaluated retrospectively and adenoma size, Knosp grade, suprasellar extension and TCTI were calculated.

    Results: The mean TCTI ratio was 1.70 (95% CI: 1.65-1.75). Intraoperatively, 140 (71.4%) adenomas were classified as soft and 48 (24.5%) as fibrous. Gross total resection was achieved in 66.7% of fibrous adenomas and in 86.4% of soft adenomas (p = 0.007). The mean score was 1.68 (95% CI: 1.62-1.74) for soft tumors and 1.76 (95%CI: 1.67-1.84) for fibrous tumors. There was no difference in the mean TCTI score between groups. Lactotroph and somatotroph adenomas had a lower mean TCTI ratio compared to other functioning and non-functioning adenomas with a mean TCTI of 1.52 compared to 1.77.

    Conclusions: In this retrospective cohort study we found that the TCTI score does not correlate with tumor consistency. We also noted that the TCTI score is increased in prolactin and growth hormone secreting adenomas.

    Patient Care: This negative finding clarifies the fact that T2-weighted MRI cannot be used to predict macroadenoma consistency. and should not be used to guide decision making and patient counseling.

    Learning Objectives: MRI use for prediction of pituitary adenoma consistency

    References:

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