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  • Preoperative Predictors of Poor Postoperative Pain Control: Systematic Review and Meta-Analysis

    Final Number:

    Michael M.H. Yang MD, M.Biotech; Rebecca Hartley; Alexander Leung; Paul Ronksley; Nathalie Jette; Steven Casha MD PhD; Jay Riva-Cambrin MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: Inadequate postoperative pain control is common and is associated with poor clinical outcomes. The goal of this systematic review was to identify preoperative predictors of poor postoperative pain control in adults undergoing inpatient surgery.

    Methods: MOOSE standards were followed. MEDLINE, EMBASE, CINAHL, and PsychInfo from inception until October 13th 2017, supplemented with a grey literature search and consultation with a pain expert. Studies in any language were included if they evaluated postoperative pain using a validated instrument (e.g. visual-analogue-scale for pain) in adults (=>18 years) and reported a measure of association between postoperative pain and at least one preoperative predictor during the hospital stay. Articles were screened and data extracted by 2 independent reviewers. Measures of association for each preoperative predictor were pooled using random effects models. Study quality was assessed using a component-based approach.

    Results: Thirty-three studies representing 53,362 patients were included in this review. Significant preoperative predictors of poor postoperative pain control included younger age (OR 1.18 [95%CI 1.05-1.32]), female sex (OR 1.29 [95%CI 1.17-1.43]), smoking (OR 1.33 [95%CI 1.09-1.61]), history of depressive symptoms (OR 1.71 [95%CI 1.32-2.22]), history of anxiety symptoms (OR 1.22 [95%CI 1.09-1.36]), sleep difficulties (OR 2.32 [95%CI 1.46-3.69]), higher BMI (OR 1.02 [95%CI 1.01-1.03]), presence of preoperative pain (OR 1.21 [95%CI 1.10-1.32]), and use of preoperative analgesia (OR 1.54 [95%CI 1.18-2.03]). Pain catastrophizing, ASA status, chronic pain, marital status, socioeconomic status, education, previous surgical history, preoperative pressure pain tolerance and orthopedic surgery (vs abdominal surgery) were not associated with poor postoperative pain control. Study quality was generally high, although appropriate blinding of exposure during outcome ascertainment was often limited in many studies.

    Conclusions: Nine significant predictors of poor postoperative pain control were identified, which may be potentially important factors to consider when developing pre- and peri-operative strategies to improve pain outcomes.

    Patient Care: An understanding of preoperative predictors of poor postoperative pain control will allow surgeons to identify patients at risk of developing poor postoperative pain control prior to surgery. This is important when anticipating pain trajectories after surgery, and developing personalized pre- and peri-operative strategies to improve pain outcomes. Identifying high-risk patients will also enable surgeons and physicians to more appropriately frame patient education and expectations.

    Learning Objectives: By the conclusion of this session, participants should be able to: 1) describe significant preoperative predictors of poor postoperative pain control, 2) understand early identification of predictors in patient at risk of postoperative pain may allow for more effective interventions, better pain management and decrease reliance on medications (particularly opioids) and 3) recognize the paucity of research in neurosurgery on preoperative predictors of poor postoperative pain control.


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