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  • Optic Radiation Mapping in Epilepsy Surgery

    Final Number:

    Roser Garcia-Armengol MD; Alicia Martinez-Piñeiro MD; Paloma Puyalto PhD; Belen Menendez; Cristina Hostalot MD; Pilar Teixidor Rodriguez; Carlos Javier Dominguez Alonso MD; Jordi Manuel de Rimbau MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: Anterior temporal lobe resection(ATLR) is a well-established and effective treatment in temporal lobe epilepsy (TLE)(1). Nevertheless, ATRL is often complicated (4-50%) by superior quadrant visual field deficits (VFDs)(2,3). In this study, we focus on comparison of the size of ATLR, the postoperative VFD, and the seizure outcome, and evaluate the correlation between distance of Meyer’s loop of the optic radiations with the margin of resection and postoperative VFD, using DTI tractrography.

    Methods: We studied 22 patients with medically refractory temporal lobe epilepsy undergoing ATLR between June 2008 and December 2016. Of the 22 patients, 6 had left- and 16 right-sided resections. Preoperative and postoperative examination of visual fields was assessed in all patients. All patients were divided into two groups. Group I ( n=12) were surgically treated without optic radiation mapping and Group II ( n=10) with guidance of radiation mapping. Optic radiation mapping include DTI tractrography and intraoperative visual evoked potentials (iVEPs).

    Results: The size of the ATLR was 4.59 +/- 1.44 cm (3.7-6 cm) and 3.74 +/-0.65 cm (3.2-4.8 cm) individually in Group I and II, respectively. The size of the ATRL was significantly smaller in Group II (p=0.0023). Five patients (25%) in Group I suffered VFDs at 3 months, whereas only one patient (10%) in Group II ( p=0.0001). Distance from the margin to resection to the initial portion of the Meyer’s loop was correlated with VFDs, with safe margin of 11.1 mm. The 6-month follow-up survey showed a good outcome in 93,7% of patients in Group I (Engel class I-II) and 90.0%m in Group II. (Table I)

    Conclusions: Optic radiation mapping can reduce the risk of visual deficits in anterior temporal lobe resection

    Patient Care: This study will prevent visual deficits in anterior temporal lobe resection in epilepsy surgery.

    Learning Objectives: 1. Know the relationships of optical radiation in ATLR 2. Determine the role of optical radiation mapping (DTI tractrography and intraoperative visual evoked potentials (IVEPs)) in Epilepsy surgery

    References: 1.Engel J Jr. Surgery for seizures. N Engl J Med 1996;334:647–52 2. Cohen-Gadol AA, Wilhelmi BG, Collignon F, et al. Long-term outcome of epilepsy surgery among 399 patients with nonlesional seizure foci including mesial temporal lobe sclerosis. J Neurosurg 2006;104:513–24 3.Krolak-Salmon P, Guenot M, Tiliket C, et al. Anatomy of optic nerve radiations as assessed by static perimetry and MRI after tailored temporal lobectomy. Br J Ophthalmol 2000;84:884 – 89

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