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  • Seizure Outcome After Surgical Sesection of Insular Glioma

    Final Number:
    380

    Authors:
    Doris D. Wang MD PhD; Shawn L. Hervey-Jumper MD; Edward F. Chang MD; Mitchel S. Berger MD

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2017 Annual Meeting

    Introduction: A majority of patients with insular tumors present with seizures. Although a number of studies have shown that greater extent of resection improves overall patient survival, few studies have documented post-operative seizure control after insular tumor resection. The aim of this study was to 1) characterize seizure control rates in patients undergoing insular tumor resection, 2) identify predictors of seizure control, and 3) evaluate the association between seizure recurrence and tumor progression.

    Methods: The study population included adults who had undergone resection of insular gliomas between 1997 and 2015 at the University of California San Francisco. Preoperative seizure characteristics, tumor characteristics, surgical factors, and postoperative seizure outcomes were reviewed.

    Results: One-hundred and nine patients with sufficient clinical data were included in the study. At one year after surgery, 74 patients (68%) were seizure free. At final follow-up, 42 patients (39%) were seizure free. Median time to seizure recurrence was 46 months (95% CI 31-65 months). Multivariate Cox regression analysis revealed that greater extent of resection (HR=0.2899 [0.1129, 0.7973], p=0.0127) was a significant predictor of seizure freedom. Of patients who had seizure recurrence and tumor progression, seizure usually recurred within 3 months prior to tumor progression. Repeat resection offered additional seizure control, as eight of the 22 patients with recurrent seizures became seizure free after re-operation.

    Conclusions: Maximizing the extent of resection in insular gliomas portends greater seizure freedom after surgery. Seizure recurrence is associated with tumor progression, and repeat operation can lead to additional seizure control.

    Patient Care: Seizures are frequent symptoms associated with insular tumors that significantly impact patients’ quality of life. Maximizing extent of tumor resection favors seizure-freedom. Seizure recurrence often occurs prior to tumor progression, and repeat surgery may offer additional benefits for long-term seizure control.

    Learning Objectives: By the end of this session, participants should be able to: 1) Identify that insular gliomas often present as seizures; 2) Describe predictors of seizure control after insular glioma resection, and 3) Understand the temporal relationship between seizure recurrence and tumor progression.

    References:

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