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  • Expression of Innate Immune Proteins in Human Gliomas

    Final Number:

    Stephanie Adamczak MD/PhD; Maryam Rahman MD MS; Jesse Kresak MD

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2016 Annual Meeting

    Introduction: The innate immune system is the body’s first line of defense against danger, either from pathogens or damaged host tissue. The central nervous system (CNS), once believed to be a victim of chemical warfare between pathogens and professional immune cells, is now recognized as an active player in the innate immune defense against not only infection, but also injured tissue and malignancy

    Methods: Here, we used immunohistochemistry to measure the expression levels of inflammasome proteins in 25 human glioma samples (both high and low-grade.)

    Results: We found that inflammasome proteins ASC, caspase-1, Pannexin-1, and NALP-1 are expressed in human gliomas. The expression pattern is highly variable, suggesting important molecular differences among both high and low-grade gliomas.

    Conclusions: This is the first characterization of inflammasome proteins in human glioma samples, and the high expression levels suggest an important role for the inflammasome in primary CNS tumor biology.

    Patient Care: Further elucidating the role of inflammasome proteins in tumorgenesis may help direct treatment.

    Learning Objectives: Gliomas express inflammasome proteins.


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