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  • Prophylactic Antiepileptic Drugs Do Not Reduce Seizure Rates in Surgical Brain Tumor Patients

    Final Number:

    Sasha Vaziri; Frank Walch; Dennis T. Lockney MD; Dan Neal MS; Gregory J. Murad MD; Maryam Rahman MD MS

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2014 Annual Meeting

    Introduction: Currently, no clear evidence supports seizure prophylaxis in patients with cerebral tumors. However, prophylactic use of anti-epileptic drugs (AEDs) for patients undergoing brain tumor surgery is common practice. We retrospectively evaluated surgical brain tumor patients at the University of Florida for AED use and seizure outcomes.

    Methods: A retrospective chart review was performed of 609 consecutive patients from 2010-2013 who underwent surgery for a brain neoplasm at the University of Florida. Inclusion criteria were all patients with intra- or extra-axial tumors. Exclusion criteria were pre-existing seizure condition prior to tumor diagnosis. Data were analyzed to determine seizure incidence, AED use, and AED toxicities.

    Results: 609 patients met inclusion criteria. Patients who did not present with seizures preoperatively were divided into supratentorial and infratentorial groups. There were 357 patients with supratentorial tumors assessed with 297 (83.2%) receiving AEDs post-operatively and 60 (16.8%) not receiving AEDs. From surgery to the last follow-up, one patient (2%) in the non-AED group had a seizure and 15 (6.2%) in the AED group had seizures (p=0.487). There were 129 patients with infratentorial tumors, with 32 (24.8%) receiving AEDs and 97 (75.2%) not receiving AEDs. In the post-operative period, one patient (1.2%) in the non-AED group had a seizure and zero in the AED group had a seizure (p=1). A total of 16 (5.4%) patients in the supratentorial group and 3 (9.4%) patients in the infratentorial group on AEDs experienced toxicity related to AEDs. At discharge, 254 patients (85.5%) with supratentorial tumors without seizures remained on AEDs. At last follow up, 129 patients (53.8%) with supratentorial tumors remained on AEDs despite no seizures.

    Conclusions: AEDs do not significantly reduce post-operative seizures in surgical brain tumor patients in this analysis. Additionally, once a patient is prescribed an AED, discontinuation of AED therapy is unlikely, even if the patient remains seizure free.

    Patient Care: Further investigation is necessary, however our results indicate that treating brain tumor patients prophylactically with anti-epileptic drugs may be exposing them to the risks of side effects of the therapy without offering a substantial benefit of seizure prophylaxis.

    Learning Objectives: By the conclusion of this session, participants should be able to thoughtfully discuss the clinical practice and appropriateness of prophylactic anti-epileptic therapy in patients with brain tumors who are undergoing surgery.


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