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  • Efficacy and Safety of Corpus Callosotomy After Vagal Nerve Stimulation in Patients with Medically Intractable Epilepsy

    Final Number:

    Jennifer Hong MD; Atman Desai MD; Kimon Bekelis MD; Jo Ling Goh; David W. Roberts MD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2013 Annual Meeting

    Introduction: Vagal nerve stimulation (VNS) and corpus callosotomy (CC) have both been shown to be of benefit in the treatment of medically refractory epilepsy. Recent case series have reviewed the efficacy of VNS in patients who are status-post CC with encouraging results. There remain little data, however, on the use of CC following VNS therapy.

    Methods: The records of all patients at our center undergoing CC following VNS between 1993 to 2013 were reviewed. Patient baseline characteristics, operative detail and post-operative outcomes were analyzed.

    Results: Ten patients met inclusion criteria. Median follow-up was 50 months (range of 10-113). Mean time between VNS and corpus callosotomy was 55.8 months. The most common reason for corpus callosotomy was progression of seizures after VNS. Nine patients had anterior corpus callosotomy and one patient returned to the OR for a completion corpus callosotomy. All patients had decrease in rate of falls and drop seizures. Four patients experienced elimination of drop seizures. One patient had a Class II outcome, eight patients had Class III outcomes, and one patient had a Class IV outcome. There were three major immediate post-operative complications. One patient developed pneumonia, one patient developed mutism which resolved, and one patient suffered a stroke resulting in mild hemiplegia and hand apraxia.

    Conclusions: CC can help reduce seizures in patients with medically refractory epilepsy following VNS, particularly with respect to drop attacks.

    Patient Care: My research will establish the safety and efficacy of novel surgical approaches to medically intractable epilepsy.

    Learning Objectives: By the conclusion of this session participants should be able to 1) Describe the indications for corpus callosotomy and vagal nerve stimulation in epilepsy 2) Discuss the efficacy of palliative surgery in medically intractable epilepsy 3) Describe complications of corpus callosotomy


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