References: Aronowski J, Zhao X. Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke 2011 Jun;42(6):1781-6. PMCID:PMC3123894
Bari A, Dalley JW, Robbins TW. The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats. Nat.Protoc. 2008;3(5):759-67
Burns JD, Manno EM. Primary intracerebral hemorrhage: update on epidemiology, pathophysiology, and treatment strategies. Compr.Ther. 2008;34(3-4):183-95
Cai Y, Cho GS, Ju C, Wang SL, Ryu JH, Shin CY, Kim HS, Nam KW, Jalin AM, Sun W, et al. Activated microglia are less vulnerable to hemin toxicity due to nitric oxide-dependent inhibition of JNK and p38 MAPK activation. J.Immunol. 2011 Aug 1;187(3):1314-21
Carmichael ST, Vespa PM, Saver JL, Coppola G, Geschwind DH, Starkman S, Miller CM, Kidwell CS, Liebeskind DS, Martin NA. Genomic profiles of damage and protection in human intracerebral hemorrhage. J.Cereb.Blood Flow Metab 2008 Nov;28(11):1860-75. PMCID:PMC2745827
Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT. Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome. J.Neurosurg. 2011 Dec;115(6):1184-90
Chen-Roetling J, Li Z, Chen M, Awe OO, Regan RF. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology 2009 Apr;56(5):922-8. PMCID:PMC2692087
Chen-Roetling J, Li Z, Regan RF. Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity. Curr.Neurovasc.Res. 2008 Aug;5(3):193-8. PMCID:PMC2556566
Day and Link (2012) Regulation of neutrophil trafficking from the bone marrow. Cell Mol.Life Sci. 69: 1415-1423.
De FK, Henderson RB, Laschinger M, Hogg N. Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J.Immunol. 2008 Mar 15;180(6):4308-15
Figueiredo RT, Fernandez PL, Mourao-Sa DS, Porto BN, Dutra FF, Alves LS, Oliveira MF, Oliveira PL, Graca-Souza AV, Bozza MT. Characterization of heme as activator of Toll-like receptor 4. J.Biol.Chem. 2007 Jul 13;282(28):20221-9
Fortes, Alves, de, Dutra, Rodrigues, Fernandez, Souto-Padron, De Rosa, Kelliher, Golenbock, Chan, Bozza (2012) Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood 119: 2368-2375.
Frank MG, Wieseler-Frank JL, Watkins LR, Maier SF. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J.Neurosci.Methods 2006 Mar 15;151(2):121-30
Gong C, Hoff JT, Keep RF. Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res. 2000 Jul 14;871(1):57-65
Han N, Ding SJ, Wu T, Zhu YL. Correlation of free radical level and apoptosis after intracerebral hemorrhage in rats. Neurosci.Bull. 2008 Dec;24(6):351-8
Hu YY, Huang M, Dong XQ, Xu QP, Yu WH, Zhang ZY. Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway. J.Ethnopharmacol. 2011 Oct 11;137(3):1462-8
Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J.Neurosurg. 2002 Feb;96(2):287-93
Ikram MA, Wieberdink RG, Koudstaal PJ. International epidemiology of intracerebral hemorrhage. Curr.Atheroscler.Rep. 2012 Aug;14(4):300-6. PMCID:PMC3388250
Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012 Aug;11(8):720-31
Kirkman MA, Allan SM, Parry-Jones AR. Experimental intracerebral hemorrhage: avoiding pitfalls in translational research. J.Cereb.Blood Flow Metab 2011 Nov;31(11):2135-51. PMCID:PMC3210340
Koltz MT, Tosun C, Kurland DB, Coksaygan T, Castellani RJ, Ivanova S, Gerzanich V, Simard JM. Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity. J.Neurosurg.Pediatr. 2011 Dec;8(6):628-39. PMCID:PMC3465975
Laird MD, Wakade C, Alleyne CH, Jr., Dhandapani KM. Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes. Free Radic.Biol.Med. 2008 Oct 15;45(8):1103-14
Lara FA, Kahn SA, da Fonseca AC, Bahia CP, Pinho JP, Graca-Souza AV, Houzel JC, de Oliveira PL, Moura-Neto V, Oliveira MF. On the fate of extracellular hemoglobin and heme in brain. J.Cereb.Blood Flow Metab 2009 Jun;29(6):1109-20
Lee MC, Heaney LM, Jacobson RL, Klassen AC. Cerebrospinal fluid in cerebral hemorrhage and infarction. Stroke 1975 Nov;6(6):638-41
Leira R, Davalos A, Silva Y, Gil-Peralta A, Tejada J, Garcia M, Castillo J. Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors. Neurology 2004 Aug 10;63(3):461-7
Levy YS, Streifler JY, Panet H, Melamed E, Offen D. Hemin-induced apoptosis in PC12 and neuroblastoma cells: implications for local neuronal death associated with intracerebral hemorrhage. Neurotox.Res. 2002 Nov;4(7-8):609-16
Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J.Neuroinflammation. 2012;9:46. PMCID:PMC3344687
Lu A, Tang Y, Ran R, Ardizzone TL, Wagner KR, Sharp FR. Brain genomics of intracerebral hemorrhage. J.Cereb.Blood Flow Metab 2006 Feb;26(2):230-52
Mackenzie JM, Clayton JA. Early cellular events in the penumbra of human spontaneous intracerebral hemorrhage. J.Stroke Cerebrovasc.Dis. 1999 Jan;8(1):1-8
Mayne M, Ni W, Yan HJ, Xue M, Johnston JB, Del Bigio MR, Peeling J, Power C. Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhage. Stroke 2001 Jan;32(1):240-8
Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G. Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res. 2005 Mar 28;1039(1-2):30-6
Piazza, Damore, Costa, Gioannini, Weiss, Peri (2011) Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets. Innate.Immun. 17: 293-301.
Rincon F, Mayer SA. The Epidemiology of Intracerebral Hemorrhage in the United States from 1979 to 2008. Neurocrit.Care 2012 Oct 26;
Rodriguez-Yanez, Brea, Arias, Blanco, Pumar, Castillo, Sobrino (2012) Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage. J.Neuroimmunol. 247: 75-80.
Rosell A, Vilalta A, Garcia-Berrocoso T, Fernandez-Cadenas I, Domingues-Montanari S, Cuadrado E, Delgado P, Ribo M, Martinez-Saez E, Ortega-Aznar A, et al. Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage. PLoS.One. 2011;6(2):e16750. PMCID:PMC3032742
Sansing LH, Harris TH, Welsh FA, Kasner SE, Hunter CA, Kariko K. Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Ann.Neurol. 2011 Oct;70(4):646-56
Silva Y, Leira R, Tejada J, Lainez JM, Castillo J, Davalos A. Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage. Stroke 2005 Jan;36(1):86-91
Simard JM, Tosun C, Ivanova S, Kurland DB, Hong C, Radecki L, Gisriel C, Mehta R, Schreibman D, Gerzanich V. Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage. Transl.Stroke Res. 2012 Jul;3(Suppl 1):155-65. PMCID:PMC3372778
Simard PF, Tosun C, Melnichenko L, Ivanova S, Gerzanich V, Simard JM. Inflammation of the Choroid Plexus and Ependymal Layer of the Ventricle Following Intraventricular Hemorrhage. Transl.Stroke Res. 2011 Jun;2(2):227-31. PMCID:PMC3128335
Sukumari-Ramesh S, Laird MD, Singh N, Vender JR, Alleyne CH, Jr., Dhandapani KM. Astrocyte-derived glutathione attenuates hemin-induced apoptosis in cerebral microvascular cells. Glia 2010 Nov 15;58(15):1858-70. PMCID:PMC2951495
Teng W, Wang L, Xue W, Guan C. Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats. Mediators.Inflamm. 2009;2009:473276. PMCID:PMC2817507
Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog.Neurobiol. 2010 Dec;92(4):463-77. PMCID:PMC2991407
Wang J, Dore S. Inflammation after intracerebral hemorrhage. J.Cereb.Blood Flow Metab 2007 May;27(5):894-908
Wang X, Mori T, Sumii T, Lo EH. Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke 2002 Jul;33(7):1882-8
Weiss SJ. Tissue destruction by neutrophils. N.Engl.J.Med. 1989 Feb 9;320(6):365-76
Wu H, Cong Y, Wang D, Zhao R, Qi J. Correlation of macrophage inflammatory protein-2 expression and brain edema in rats after intracerebral hemorrhage. Int.J.Clin.Exp.Pathol. 2009;2(1):83-90. PMCID:PMC2491385
Wu H, Zhang Z, Hu X, Zhao R, Song Y, Ban X, Qi J, Wang J. Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study. Brain Res. 2010 Jun 25;1342:111-7. PMCID:PMC2885522
Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J.Neurosurg. 1998 Dec;89(6):991-6
Xue M, Del Bigio MR. Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death. Neurosci.Lett. 2000 Apr 14;283(3):230-2
Zhao X, Zhang Y, Strong R, Grotta JC, Aronowski J. 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. J.Cereb.Blood Flow Metab 2006 Jun;26(6):811-20
Zhou H, Andonegui G, Wong CH, Kubes P. Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J.Immunol. 2009 Oct 15;183(8):5244-50