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  • Analgesic Efficacy of Diclofenac Sodium in Reducing the Total Dose of Morphine Injection and Its Adverse Effect After Lumbar Disc Surgery

    Final Number:

    Yazdan Dokht Ghafari M.; Mohamad Shimia Associate's Professor

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2012 Annual Meeting

    Introduction: Inadequate pain management after lumbar disc surgery may result in increasing morbidity and length of hospital stay. This study aimed to evaluate the analgesic efficacy of diclofenac sodium in reducing the total dose of morphine and its adverse effects after lumbar disc surgery.

    Methods: Eighty-four patients with mean age of 51.74 ± 5.76 years were included in this study. After surgery, patients randomly assigned to 1 of 2 treatment groups: group A: diclofenac sodium supposition and group B: placebo. Patients were premedicated with diclofenac sodium supposition or placebo before surgery .Visual analog scale and morphine consumption were recorded at 6 hours intervals up to 24 hours.

    Results: The base line mean pain relief and nausea and urinary retention were not statistically significant between groups (P >0.05) .Weakness and fatigue, Dry mouth and Total morphine dose were statistically significant (P <0.05).constipation and skin reactions as adverse effect of morphine were not assessable in our study.

    Conclusions: Premedication whit diclofenac sodium supposition in the patients underwent lumbar disc surgery, can reduce total dose of morphine consumption after lumbar disc surgery and some adverse effect of morphine such as dry mouth, weakness and fatigue.

    Patient Care: premedication with diclofenac sodium leads to reduce total dose of morphine consumption, it's adverse effect and length of hospital stay.

    Learning Objectives: Premedication with diclofenac sodium can reduce total dose of morphine and some adverse of morphine


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