Neurosurgery Watch

Stay up to date with the latest clinical findings in Neurosurgery Watch. Each month, our panel identifies and summarizes key points of selected significant papers from over 50 journals. We emphasize the most significant findings that potentially change clinical management or treatment of neurological diseases.

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John S. Kuo, MD PhD FACS
Austin, Texas
Co-Editor
Robert Starke, MD MSc
Miami, Florida 
Co-Editor
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Resection Bed Radiosurgery Improves Local Control for Brain Metastases

February 3, 2014
Stereotactic & Functional, Tumor
By: 
Jonathan Sherman, MD
J. Bradley Elder, MD
Source: 
http://journals.lww.com/neurosurgery/Abstract/2013/12000/Predicting_Tumor_Contro...

Current management of brain metastases frequently involves stereotactic radiosurgery (SRS) and/or whole brain radiation therapy (WBRT) after surgery. This study examines factors associated with SRS to the surgical bed after brain metastasis resection. Overall, 86% of 120 patients achieved local...

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Dose-Dense Temozolomide Is Not Superior to Standard Dose Temozolomide for Glioblastoma

January 2, 2014
Tumor
By: 
Clark C. Chen, MD PhD
Source: 
PubMed

Escalating temozolomide dose regimen beyond that used in standard therapy, termed the dose dense regimen, has been proposed as a means to functional deplete MGMT and improve temozolomide efficacy in the management of glioblastoma. This randomized control trial evaluated 883...

ARUBA Trial: Greater Early Risk With Interventional Management of Unruptured AVM Than With Observation Alone

January 2, 2014
By: 
Alexander A. Khalessi, MD
Source: 
PubMed

The ARUBA Trial randomized patients with unruptured arteriovenous malformations (AVM) to medical management versus multi-modal therapy. As published in the Lancet, the Data Safety and Monitoring Board (DSMB) prematurely halted the trial at 223 patients (55% enrollment) due to inferior...

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Seventy Percent Reduction in Transcranial Motor Evoked Potential Is Most Valid Measure of Neurological Worsening During Complex Spine Surgery

January 2, 2014
Spine
By: 
S. R. Manoharan, MBBS
H. Francis Farhadi, MD PhD
Source: 
Journal of Neurosurgery

The Japanese Society for Spine Surgery and Related Research published a prospective multicenter spinal intraoperative monitoring (IOM) study conducted across 18 institutions with 959 patients undergoing surgery for deformity correction, ossification of the posterior longitudinal ligament, or tumor resection between...

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Predictive Factors of Clinically Relevant Improvement After Anterior Cervical Decompression and Fusion: 10- to 13-Year Follow-Up

December 1, 2013
Spine
By: 
John H. Shin, MD
Source: 
Journal of Neurosurgery

Hermansen et al. report long-term results of a prospective, randomized study evaluating ACDF outcomes. Clinically relevant improvement (CRI) was defined as ≥ 30-mm improvement on a visual analog scale and ≥ 20% improvement in the neck disability index from preoperative...

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