Neurosurgery Watch

Stay up to date with the latest clinical findings in Neurosurgery Watch. Each month, our panel identifies and summarizes key points of selected significant papers from over 50 journals. We emphasize the most significant findings that potentially change clinical management or treatment of neurological diseases.

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John S. Kuo, MD PhD FACS
Madison, Wisconsin
Co-Editor
Robert Starke, MD MSc
Miami, Florida 
Co-Editor
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TU

Temozolomide chemoradiation improves survival in high risk low grade gliomas in phase II trial.

April 28, 2015
Tumor
By: 
J. Bradley Elder, MD
Source: 
Radiation Oncology

The role of adjuvant chemotherapy in patients with low grade gliomas remains unclear. The authors report initial results from a phase 2 clinical trial (RTOG 0424) in which 129 patients with high-risk low grade gliomas (LGG) were treated with radiation...

CV

Balloon-mounted stents are not superior to antiplatelet therapy for symptomatic intracranial stenosis

April 28, 2015
Cerebrovascular
By: 
Alexander A. Khalessi, MD
Source: 
Journal of American Medical Association

The VISSIT trial examined the safety and efficacy of intracranial stenting versus antiplatelet medical therapy for symptomatic intracranial atherosclerotic disease (ICAD), similar to the SAMMPRUS trial.  Target lesions included stenosis greater than 70%; primary endpoint was the secondary prevention of...

SP

Surgical correction of adult spinal deformity improves back and leg pain

March 30, 2015
Spine
By: 
John S. Kuo, MD PhD
Source: 
Journal Neurosurgery Spine

Analysis of a prospectively collected, multi-center database of 421 adult spinal deformity (ASD) patients (235 surgical, 186 non-surgical patients) by the International Spine Study Group showed that surgical patients were 6.2 times more likely to experience improvement in back pain,...

CV

ESCAPE: Rapid endovascular treatment improves functional outcomes in stroke

February 26, 2015
Cerebrovascular
By: 
Alexander A. Khalessi, MD
Source: 
PubMed

The ESCAPE Trial aimed to assess the role for thrombectomy for patients with stroke due to anterior circulation proximal vessel occlusion. The study randomized 316 patients across 22 centers worldwide who presented within 12 hours with an acute stroke syndrome...

CV

EXTEND-IA: Rapid endovascular treatment based on perfusion imaging improves functional outcomes in stroke

February 26, 2015
Cerebrovascular
By: 
Alexander A. Khalessi, MD
Source: 
PubMed

The Extend-IA multicenter randomized trial conducted in Australia and New Zealand included patients with a confirmed anterior circulation occlusion who received IV alteplase (0.9 mg/kg) within 4.5 hours of symptom onset.  All patients received CT perfusion imaging and we’re excluded...

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