Neurosurgery Watch

Stay up to date with the latest clinical findings in Neurosurgery Watch. Each month, our panel identifies and summarizes key points of selected significant papers from over 50 journals. We emphasize the most significant findings that potentially change clinical management or treatment of neurological diseases.

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John S. Kuo, MD PhD FACS
Austin, Texas
Co-Editor
Robert Starke, MD MSc
Miami, Florida 
Co-Editor
Search Neurosurgery Watch
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Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial

July 5, 2018
Cerebrovascular
By: 
Vincent Y. Wang, MD, PhD
Source: 
Lancet

Spontaneous intracerebral hemorrhage (ICH) is a common cause of mortality and disability.  Tranexamic acid (TXA) is an antifibrinolytic agent that has been shown to reduce mortality in patients with traumatic injury and postpartum hemorrhage.  The Tranexamic acid for hyperacute primary...

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Tenectaplase versus Alteplase before Thrombectomy for Ischemic Stroke: EXTEND-IA TNK Trial

July 5, 2018
Cerebrovascular
By: 
Andrew W. Grande, MD
Shailesh Male, MD
Source: 
NEJM

EXTEND-IA TNK is a multicenter, randomized, open-label, blinded-outcomes, non-inferiority trial of acute ischemic stroke patients with internal carotid, middle cerebral, or basilar artery occlusion eligible for both intravenous thrombolysis. Patients were randomized 1:1 to receive IV tenecteplase (0.25mg/kg; max dose...

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Restenosis & risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study: secondary analysis of a RCT

July 5, 2018
Cerebrovascular
By: 
Stephen Grupke, MD
Source: 
Lancet Neurology

The International Carotid Stenting Study examined 1713 patients across 50 centers with symptomatic carotid stenosis (50% or greater) who were randomized to angioplasty and stenting vs endarterectomy in a 1:1 ratio.  Patients were followed at 30 days, 6 months, and...

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Contact Aspiration Versus Stent Retriever in Patients with Acute Ischemic Stroke with M2 Occlusion in the ASTER Randomized Clinical Trial.

May 1, 2018
Cerebrovascular
By: 
Robert M. Starke, MD MSC
Source: 
JAMA

Middle cerebral artery M2-segment occlusions represent an important subgroup of patients with acute stroke with large-vessel occlusion. The safety of mechanical thrombectomy in distal occlusions remains unclear. In a post hoc analysis of the ASTER trial (Contact Aspiration Versus Stent...

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Guidelines for Deep Brain Stimulation Treatment of Parkinson’s Disease: GPI vs STN

May 1, 2018
Stereotactic & Functional
By: 
Ellen L. Air, MD, PhD
Source: 
Neurosurgery

Deep Brain Stimulation (DBS) is an established treatment for Parkinson’s Disease (PD).  A debate remains over the optimal target (Subthalamic Nucleus STN or Globus Pallidus Internus GPi). The CNS guidelines reviews Class I evidence to address specific questions regarding target...

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