Tumor

The most recent findings related to tumors are available from Neurosurgery Watch.

TU

Guidelines for the Management of Nonfunctional Pituitary Adenomas

October 31, 2016
Tumor
By: 
Jason Heth, MD
Source: 
Congress of Neurological Surgeons

Nonfunctioning pituitary adenomas (NFPAs) are a unique subset of pituitary tumors.  While NFPA treatment may seem straightforward, there are many alternatives in their evaluation and management.   To examine the evidentiary support of these alternatives, the Congress of Neurological Surgeons...

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Radiosurgery with and without whole brain radiation for metastases: A randomized clinical trial

August 30, 2016
Stereotactic & Functional, Tumor
By: 
Jonathan Sherman, MD
Source: 
JAMA

A prospective, multicenter, randomized cohort trial compared the post-treatment cognitive function of patients with 1 to 3 brain metastases treated with either stereotactic radiosurgery alone (SRS) (n = 111) or stereotactic radiosurgery plus whole brain radiation therapy (WBRT) (n=102). The...

TU

Radiation plus PCV improves long-term overall survival in patients with low grade glioma

May 2, 2016
Tumor
By: 
Nader Sanai, MD
Source: 
New England Journal of Medicine

As a follow-up to the 2012 results of a randomized Phase III trial adding procarbazine, lomustine (CCNU), and vincristine (PCV) chemotherapy after radiotherapy for newly-diagnosed patients with WHO grade II glioma, this new report details the long-term results after 12...

TU

Tumor-Treating fields for Newly Diagnosed Glioblastoma

February 5, 2016
Tumor
By: 
John S. Kuo, MD PhD
Kyle I Swanson, MD
Source: 
JAMA

Tumor-treating fields (TTFields) are transcutaneously delivered alternating electric fields previously approved for treating recurrent glioblastoma. TTFields are hypothesized to have an anti-mitotic activity that impedes cellular proliferation. Stupp et al.1 recently reported an interim analysis of a Phase III multicenter...

TU

Genomic Analysis Identifies New Prognostic Molecular Subtypes of Diffuse Lower-Grade Gliomas

July 30, 2015
Tumor
By: 
Nader Sanai, MD
Source: 
NEJM

The Cancer Genome Atlas Research Network characterized low-grade gliomas through a genome-wide analysis of 293 previously-untreated adult lower-grade glioma: oligodendrogliomas (n=116), astrocytomas (n=100), and oligoastrocytomas (n=77).  Overall, data from DNA copy number, RNA, and DNA methylation status demonstrated three distinct...

TU

Temozolomide chemoradiation improves survival in high risk low grade gliomas in phase II trial.

April 28, 2015
Tumor
By: 
J. Bradley Elder, MD
Source: 
Radiation Oncology

The role of adjuvant chemotherapy in patients with low grade gliomas remains unclear. The authors report initial results from a phase 2 clinical trial (RTOG 0424) in which 129 patients with high-risk low grade gliomas (LGG) were treated with radiation...

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Clinical Practice Guideline Update for Acromegaly

January 29, 2015
Tumor
By: 
John S. Kuo, MD PhD
Source: 
Journal of Clinical Endocrinology & Metabolism

An updated clinical practice guideline on acromegaly formulated by an expert task force jointly sponsored by the Endocrine Society and European Society of Endocrinology was recently released. Diagnostic serum IGF-1 assay is recommended in patients with acromegaly features, or with...

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Reoperation for Recurrent High-Grade Glioma: A Current Perspective of the Literature

January 5, 2015
Tumor
By: 
Jonathan Sherman, MD
J. Bradley Elder, MD
Source: 
Pub Med

Reoperation for recurrent WHO grade III and IV high-grade glioma can be an important part of the treatment strategy. The authors provide a comprehensive review of the published literature regarding this topic, including papers from January 1980 to August 2013. ...

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Predictors of progression and role of adjuvant radiation for atypical meningiomas

November 4, 2014
Tumor
By: 
Gavin P. Dunn, MD PhD
Gabriel Zada, MD
Source: 
Pub Med

The role of radiation therapy following subtotal resection (STR) of atypical meningiomas remains unclear.  Sun and colleagues therefore retrospectively evaluated predictors of radiographic progression in 59 patients with STR of atypical meningiomas treated with varied postoperative strategies. Patients treated with...

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Stereotactic radiosurgery alone for patients with up to 10 brain metastases

April 30, 2014
Stereotactic & Functional, Tumor
By: 
Clark C. Chen, MD PhD
Source: 
Lancet Oncology

The role of stereotactic radiosurgery (SRS) for patients with multiple metastases remains uncertain.  A prospective observational study published in Lancet Oncology evaluates the use of SRS without addition of whole brain irradiation on survival for 1194 patients (KPS>70) with 1-10...

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