Neurosurgery Watch

Stay up to date with the latest clinical findings in Neurosurgery Watch. Each month, our panel identifies and summarizes key points of selected significant papers from over 50 journals. We emphasize the most significant findings that potentially change clinical management or treatment of neurological diseases.

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John S. Kuo, MD PhD FACS
Madison, Wisconsin
Co-Editor
Robert Starke, MD MSc
Miami, Florida 
Co-Editor
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TU

Tumor-treating fields plus temozolomide versus temozolomide alone for GBM patients

February 1, 2018
Tumor
By: 
Jonathan Sherman, MD
J. Bradley Elder, MD
Source: 
JAMA

Standard adjuvant therapy after GBM resection is radiation therapy (RT) with concomitant temozolomide (TMZ) followed by maintenance TMZ. Tumor-treating fields (TTFields), consisting of low-intensity, alternating electric fields delivered via transducer arrays applied to the scalp. Addition of tumor-treating fields to...

TU

Guidelines for Vestibular Schwannoma Management

February 1, 2018
Tumor
By: 
Jonathan Sherman, MD
J. Bradley Elder, MD
Source: 
Neurosurgery

Managing vestibular schwannoma patients requires a multidisciplinary team approach that incorporates neurosurgery, otolaryngology, and radiation oncology. Neuro-radiology, pathology, intra-operative monitoring, and neuro-oncology are also important components. The Guidelines for the Treatment of Adults with Vestibular Schwannoma were recently introduced, providing...

CV

National Patterns of Carotid Revascularization Before and After the Carotid Revascularization Endarterectomy vs Stenting Trial (CREST)

February 1, 2018
Cerebrovascular
By: 
Stephen Grupke

CREST demonstrated subtle advantage of carotid endarterectomy (CEA) compared to carotid artery stenting (CAS) in subgroup analysis. Specifically, patients receiving CEA had lower rates of stroke despite no difference in composite outcomes which included myocardial ischemia. In the present study,...

CV

DEFUSE 3: Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

February 1, 2018
Cerebrovascular
By: 
Andrew W. Grande, MD

DEFUSE-3 is a randomized clinical trial comparing endovascular therapy and standard medical management with medical management alone in anterior circulation large vessel occlusion (LVO) acute ischemic stroke (AIS) patients presenting within 6 to 16 hours from last well-known time with...

PE

Endoscopic Treatment versus Shunting for Infant Hydrocephalus

January 1, 2018
Pediatrics
By: 
Raheel Ahmed, MD
Source: 
NEJM

Endoscopic treatment of hydrocephalus in developing countries enables effective CSF diversion. Yet, several studies have demonstrated relative ventriculomegaly despite successful CSF shunting in patients undergoing endoscopic third ventriculostomy and choroid plexus cauterization (ETV-CPC) versus ventriculoperitoneal shunting (VPS). The secondary effects...

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