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  • Outcome in Patients Undergoing Stereotactic Radiosurgery: Frailty is Associated with Worse Short-term Outcomes

    Final Number:

    Anthony O Asemota MD MPH; Gary L. Gallia MD

    Study Design:

    Subject Category:

    Meeting: 2018 ASSFN Biennial Meeting

    Introduction: Frailty assessment is a burgeoning area of interest and its usefulness for predicting outcomes has been examined for major surgical procedures. However its impact on outcome of patients undergoing stereotactic radiosurgery (SRS) has not yet been evaluated. Employing a national database, we sought to examine the impact of frailty on outcome of patients undergoing SRS.

    Methods: All patients who underwent inpatient procedures of SRS were identified from the Nationwide Inpatient Sample database 2001-2010 using ICD-9-CM codes. Frailty assessment employed the validated Johns Hopkins Adjusted Clinical Groups indicator. Standard descriptive techniques and matched propensity score analyses adjusted for multiple confounders examined outcomes.

    Results: Among 37,973 cases, frailty was present in 3.08%. The mean age for frail versus non-frail patients was 60.02 years (SD±18.39) vs. 56.63 years (SD±18.05), (p<0.001). Frail patients were more likely to possess Medicare/Medicaid insurance (p<0.001), lower median income (p<0.001), and have higher comorbidity (p<0.001). Most SRS procedures occurred at teaching hospitals (85.39%), large bed-size hospitals (72.94%), in urban areas (96.50%), and in the North-east (39.07%). The commonest indication for SRS was secondary brain metastases (33.35%), and the commonest SRS modality utilized was multi-source photon (gamma knife) in 53.28%. Overall mortality was 0.82%. Frail patients demonstrated significantly higher mortality (3.10% vs. 0.75%, p<0.001) and were more likely for non-routine discharges (61.95% vs. 23.84%, p<0.001). There was a higher incidence of neurologic complications among frail patients (3.30% vs. 1.04%, p<0.001). The mean total charge associated with SRS was $54,942.24 (95%CI=$53,673.48-56,210.99), and was significantly higher among frail patients [$109,015.70 (95%CI=$92,905.60-125,125.90) vs. $53,208.27 (95%CI=$52,024.47-54,392.07), p<0.001]. Total length of hospitalization was significantly prolonged among frail patients [14.06 days (95%CI=12.12-16.00) vs. 4.16 days (95%CI=4.02-4.31), p<0.001].

    Conclusions: Frailty is associated with worse short-term outcomes among inpatients undergoing SRS. Additional studies to more fully understand the particular role and benefits of frailty in pre-operative risk-stratification and assessment are needed.

    Patient Care: By informing on factors that affect prognosis of patients undergoing stereotactic radiosurgery.

    Learning Objectives: To highlight risk factors useful for pre-operative assessment and evaluation of patients undergoing stereotactic radiosurgery procedures.


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