• Methamphetamine related spontaneous hemorrhagic stroke and the prevalence of underlying vascular lesions

    Final Number:

    Robert WJ Ryan MD, FRCS(C), MSc; Amir Khan

    Study Design:
    Clinical trial

    Subject Category:
    Intracranial Hemorrhage/Critical Care

    Meeting: AANS/CNS Cerebrovascular Section 2015 Annual Meeting

    Introduction: Methamphetamine use has been associated with increased risk of hemorrhagic stroke. This has been reported to occur in younger patients, and with worse outcomes compared to non-drug related hemorrhages in patients with aneurysmal subarachnoid hemorrhage. The mechanism for methamphetamine associated hemorrhage is not fully understood, but may be related to necrotizing angiitis and other vessel wall pathology in addition to periods of uncontrolled, extreme hypertension. This investigation explored the demographic features of patients presenting to our emergency department with methamphetamine associated hemorrhages, and the likelihood they harbored an underlying vascular lesion.

    Methods: A retrospective review of patients presenting to the emergency department with spontaneous hemorrhagic stroke (subarachnoid, intracerebral, or intraventricular hemorrhage) and urine toxicology screen positive for methamphetamines from August 2013 to September 2014. Demographic information and cerebral vascular imaging (CT or catheter angiogram) were recorded, to identify patients with an underlying aneurysm, arteriovenous malformation, or no vascular lesion identified. Results of lesion specific treatment and patient outcome were reviewed.

    Results: 17 patients identified in this time that met the criteria of a spontaneous hemorrhagic stroke and positive urine methamphetamine screen, 10 males and 7 females with the average age 42.7 years (18-61). Six patients had ruptured aneurysms, 5 had ruptured arteriovenous malformations and 6 had no underlying lesion identified; there was no significant difference in age among these patients. Treatment was directed at the patients underlying lesion.

    Conclusions: Patients with methamphetamine associated spontaneous hemorrhagic stroke frequently harbor an underlying vascular malformation, either aneurysm or arteriovenous malformation, including many older patients not commonly associated with drug use. We believe routine urine toxicology screening for patients with spontaneous hemorrhagic stroke is justified, and patients positive for methamphetamine warrant further cerebrovascular imaging to look for underlying vascular lesions.

    Patient Care: Identify patients that may need further treatment of underlying lesions to prevent rebleeding

    Learning Objectives: Identify patients with spontaneous hemorrhage and drug use at high risk for underlying vascular lesions needing treatment

    References: Kaye S, Darke S, Duflou J, McKetin R. Methamphetamine-related fatalities in Australia: demographics, circumstances, toxicology and major organ pathology. Addiction 2008;103:1353-1360. (2) Beadell NC, Thompson EM, Delashaw JB, Cetas JS. The deleterious effects of methamphetamine use on initial presentation and clinical outcomes in aneurysmal subarachnoid hemorrhage. J Neurosurg 2012;117:781-786. (3) Ho EL, Josephson SA, Lee HS, Smith WS. Cerebrovascular complications of methamphetamine abuse. Neurocrit Care 2009;10:295-305. (4) McGee SM, McGee DN, McGee MB. Spontaneous intracerebral hemorrhage related to methamphetamine abuse: autopsy findings and clinical correlation. Am J Forensic Med Pathol 2004;25:334-337. (5) Miyashita T, Hayashi T, Ishida Y, Tsuneyama K, Kimura A, Kondo T. A fatal case of pontine hemorrhage related to methamphetamine abuse. J Forensic Leg Med 2007;14:444-447. (6) Shibata S, Mori K, Sekine I, Suyama H. Subarachnoid and intracerebral hemorrhage associated with necrotizing angiitis due to methamphetamine abuse--an autopsy case. Neurol Med Chir (Tokyo) 1991;31 (7) McEvoy A, Kitchen N, Thomas D. Intracerebral haemorrhage and drug abuse in young adults. Br. J. Neurosurgery 2000; 14(5):449-454. (8) Moon K, Albuquerque F, Mitkov M, Ducruet A, Wilson D, Crowley R, Nakaji P, McDougall C. Methamphetamine use is an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage. J Neurointervent Surg 2014; 0:1-5

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