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  • Deep Brain Stimulation for Thalamic Pain Syndrome with additional lead for Dystonia

    Final Number:

    Mario Zanaty MD; Marshall Holland; Royce Woodroffe MD; Jeremy D.W. Greenlee MD; Chandan G. Reddy MD

    Study Design:

    Subject Category:
    Functional Neurosurgery

    Meeting: 2016 ASSFN Biennial Meeting Late Breaking

    Introduction: Thalamic pain syndrome is known to be refractory to medications and difficult to control. We present the first case of thalamic pain syndrome associated with dystonia that was treated with deep brain stimulation (DBS).

    Methods: This is a case report of a 60-year-old female who suffered a right posterior cerebral artery stroke after aneurysm clipping complicated by thalamic pain syndrome which developed in a delayed fashion. This was manifested by severe left-sided face and body allodynia and hyperesthesia, and was associated with marked left-sided dystonia. Her symptoms were progressive and refractory to conservative management. The pain was disabling and debilitating. After multidisciplinary discussion, the patient underwent stereotactic right-sided lead implantation in the ventral capsule/ventral striatum for pain and right-sided stereotactic lead in the globus pallidus interna for dystonia, with microelectrode recording. A single impulse generator (IPG) was implanted. The leads placement and the IPG placement were performed in a single stage under general anesthesia.

    Results: The surgery was successful without complications. She had marked improvement in her dystonia, with successful programming. Her affective component of pain improved subjectively but required multiple programming session and adjustment over time. She was able to reduce her pain medication consumption. The patient was satisfied with the results and her surrounding reported marked improvement and re-integration to society. She continued however to have intermittent breakthrough spells of severe pain. Unfortunately, she died from small cell lung carcinoma a year after her DBS surgery.

    Conclusions: Deep brain stimulation targeting multiple networks is feasible and safe. It seems feasible and successful for pain management but would require multiple programming sessions.

    Patient Care: Patient who suffer from central pain syndrome are refractory to medical management. This is a case report to add to the litterature about the effectiveness of DBS in such population. Also, post-stroke patient can have additional neurological disorder that are amenable to DBS targeting different centers. We report that this could be done in a safe and effective matter.

    Learning Objectives: Deep brain stimulation is feasible and effective for thalamic pain syndrome, however, subsequent programming to achieve adequate control can be challenging and time consuming


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