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  • Preservation of Facial Nerve Function in the Resection of Large Vestibular Schwannoma: Our Institutional Experience

    Final Number:
    2024

    Authors:
    Jehad Zakaria MD; Kurt Grahnke BA; Loren Riedy BS; Caroline Szujewski; John P. Leonetti MD; Douglas E. Anderson MD, FAANS

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: The ideal treatment for large Vestibular Schwannomas (VS) is complete removal with preservation of neurologic function. However, several recent streams of information made it clear that facial nerve (FN) preservation appropriately eclipsed gross total resection as the primary goal of surgery. We present data from large VS with objective intraoperative quantification of residual tumor size and analyze factors related to tumor control and FN preservation.

    Methods: We retrospectively reviewed 872 cases of VS operated on at our institution and confined this study to those who were operated on between 2005-2017 with tumors > 2.5 cm in largest extracanicular diameter (n=170). We analyzed patient demographics, presenting symptoms, and extent of resection (documented by intraoperative measurements of residual tumor size) with respect to tumor control and FN outcomes.

    Results: Average age was 49 (range: 9-79). Average tumor size was 3.3cm with the largest tumor measuring 7.0 cm in greatest diameter. At last follow-up 85% of patients had good FN function (HB I & II), 9% had moderate FN function (HB III) and 6% had poor FN function (HB IV-VII). In total, 68 patients (40%) had residual tumors postoperatively with an average longest of diameter 8mm. Seven patients (4%) required retreatment in the form of radiosurgery (n=2) and repeat surgical resection (n=5). Patients who required retreatment tended to have larger residuals (14.9mm) than those who did not (7.9mm), but this was not statistically significant. Additionally, all patients requiring retreatment in any form had good (n=6) or moderate (n=1) FN function

    Conclusions: We suggest leaving tumor behind in VS surgery is a viable option in order to preserve good FN function. While the percentage of patients requiring retreatment is low, it is possible to sustain good FN function in these cases. Additionally, the amount of tumor left behind may be an important factor for predicting recurrence.

    Patient Care: - provide data to indicate that surgical resection of large VS can be safely completed with facial nerve preservation - indicate that in cases where a subtotal resection is undertaken to preserve facial nerve function, appropriate follow up and safe management of tumor residual/recurrence is possible with continued facial nerve preservation - this information is helpful for skull base surgeons who have to advise patients on the best clinical/surgical approach to ensure maximal functionally safe resection for thee lesions

    Learning Objectives: - gross total resection of VS is ideal, however, functional outcome in regards to facial nerve function is critical - special attention should be paid to facial nerve function in the resection of VS - subtotal resection with facial nerve preservation is an acceptable outcome from both a functional and oncologic perspective

    References:

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