Skip to main content
  • Zero-Profile Implant for Three and Four Level ACDF. A Radiological and Clinical Analysis Focusing on Sagittal Alignment and Neurological Outcome

    Final Number:

    Giuseppe Barbagallo MD; Gianluca Scalia MD; Massimiliano Maione MD; Francesco Certo MD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: The purpose of this study is to analyze the efficacy and safety of zero-profile implants in multilevel ACDF, to evaluate the long-term results in a wide single Institution series, to compare the clinical and radiological postoperative outcomes to the data in the literature, to correlate the clinical status to the sagittal cervical profile.

    Methods: We prospectively followed 24 patients (14 male and 10 female) with multilevel cervical spondylosis undergoing underwent ACDF with zero-profile implants. The mean clinical follow-up was 39 ± 17.4 months (range 24 – 72 months). Postoperative X-ray and CT evaluation of fusion and implant-associated complications was done. The alignment of the cervical spine was measured by Cobb angle between C2 and C7, given by the intersection of two straight lines tangent to the vertebral endplates, the bottom of C2 and the upper C7, on the standing lateral cervical x-ray.

    Results: Radiographic fusion was achieved in 90% of implants, according to Pitzen criteria. Mean neck pain VAS score decreased from a 6.7 ± 2.9 to 1.6 ± 2.3 (P<0.01). Mean arm pain VAS score decreased from 5.9 ± 2.9 to 0.9 ± 1.4 (P<0.01). There were significant improvements (P<0.01) in SF36 and NDI following surgery. The cervical Cobb angle had a significant correction when compared with yhat before the operation.

    Conclusions: A zero-profile integrated plate and spacer device for ACDF surgery appears to have biomechanical properties, stability and to produce clinical and radiological outcomes that are comparable to those for nonintegrated plate and spacer constructs. It allows decompression of neural structures and high fusion rates with low complication rates.

    Patient Care: Multilevel ACDF is a safe and effective surgical option in three and four level CSM

    Learning Objectives: 1. To understand the clinical applications of zero-profile implants for multilevel ACDF 2. To discuss pros and cons fo multilevel ACDF for cervical spondylotic myelopathy 3. To investigate the advantages of multilevel ACDF in restoration of cervical lordosis and understand the importance of sagittal alignment in determining clinical outcome


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy