Skip to main content
  • Long-term Functional Outcome Following Selective Dorsal Root Rhizotomy for Spastic Cerebral Palsy – A Natural History-Matched Prospective Cohort with 15 Years Follow-up

    Final Number:

    Christian Iorio-Morin MD PhD; Rita Yap; Chantal Poulin; Marie-Andrée Cantin; Thierry Benaroch; Jean-Pierre Farmer

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: Spastic cerebral palsy (CP) can result in a wide spectrum of disability. Selective dorsal root rhizotomy (SDR) has been shown to improve spasticity in CP, although the long-term benefit of this procedure on motor function remains unclear given the improvement expected from the natural history. The goal of this study was to compare the evolution of motor function in SDR patients to their expected evolution based on Canadian developmental curve normograms.

    Methods: We performed a retrospective analysis of prospectively collected data. Patients who underwent SDR at our center between 1994 and 2016 were analysed. Pre-operative GMFCS and GMFM-88 assessments were performed by a qualified physiotherapist and recorded on video. Follow-up GMFM-88 were then performed at 1, 2, 3, 5, 10 and 15 years post-operatively. GMFM-88 scores were converted to GMFM-66 using a validated method and plotted against a GMFM-66 normogram stratified by pre-operative GMFCS. A linear mixed model analysis was then used to compare SDR patients to their expected evolution based on natural history.

    Results: 197 patients were eligible for inclusion. The median age at the time of surgery was 4.8 years (range 2.9-9.3). Median pre-op GMFM-66 was 52.1 (range 36.4-76.8). Crude median post-op GMFM-66 was 56.2, 61.8, 61.2 and 66.7 at 1, 5, 10 and 15 years respectively. The SDR cohort had statistically significantly higher GMFM-66 scores for all GMFCS classes. The 10-year advantage GMFM-66 over the expected natural history was 6.6 ± 3.8, 8.3 ± 2.5 and 4 ± 2.4 for GMFCS 1 & 2, 3 and 4 respectively. Given the published minimum clinically important difference of 1.3, these results are both statistically and clinically significant. This represented a percentile increase of 20, 40 and 25 respectively.

    Conclusions: Patients who underwent SDR show a statistically significant and clinically meaningful improvement in motor function compared to their expected natural history. This improvement is maintained at 10 years post-operatively.

    Patient Care: This study demonstrates the usefulness of selective dorsal root rhizotomy in children with spastic cerebral palsy.

    Learning Objectives: Discuss the effectiveness of selective dorsal root rhizotomy in spastic cerebral palsy


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy