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  • Management of Iatrogenic Spinal Cerebrospinal Fluid Leaks: A Cohort of 124 Patients

    Final Number:

    Royce Woodroffe MD; Logan Helland MD; Kirill Nourski; Patrick W. Hitchon MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: Cerebrospinal fluid (CSF) leaks are a frequent complication of spinal surgery, with reported rates between 2 and 20%. Management is highly variable and options include primary repair, CSF drainage, the use of fibrin sealant or some combination of the above. Using a retrospective cohort the authors aim to identify the appropriate management of iatrogenic spinal CSF leaks.

    Methods: We queried our institutional database for iatrogenic CSF leaks between 1/1/2004 and 3/14/2017 using Current Procedural Terminology (CPT) and International Classification of Disease (ICD) codes. Excluded were patients who had primarily intradural procedures; tethered cord release, tumor resection, posterior fossa decompression, etc. Information regarding patient demographics, surgical characteristics and post-operative course was gathered, including whether primary closure (with non-absorbable suture) was possible, lumbar drain placement at initial surgery, use of fibrin sealant, number of subsequent explorations, rate of infection, length of stay, and number of hospital admissions.

    Results: Our cohort consisted of 124 patients who suffered iatrogenic CSF leak out of 3,965 procedures, for a rate of 3.1%. Primary closure (+/- lumbar drain) was attempted in 64 patients, with successful repair in 47 (73.4%). Lumbar drain placement (+/- primary closure) was performed in 49 with success in 43 (87.8%). Delayed exploration of the surgical wound was required in 34 patients. Patients in whom primary closure could not be achieved and did not have a lumbar drain had a 39.5% exploration rate. Patients who required exploration had statistically significant increases in length of stay (19.6 vs. 7.8 days), hospital admissions (2.1 vs. 1.0) and infections (15 vs. 0).

    Conclusions: Primary repair of the leak and use of fibrin sealant, upon discovery, with consideration of lumbar drain, should be performed whenever possible, as they are associated with the shorter hospital stays, fewer hospital admissions, and lower rates of reoperation and infection.

    Patient Care: Improving the management of CSF leaks, has the ability to decrease length of stay, number of hospital admissions, number of reoperations, and reduce infection.

    Learning Objectives: Identify the appropriate management of iatrogenic spinal cerebrospinal fluid (CSF) leaks.

    References: Du JY, Aichmair A, Kueper J, et al. Incidental durotomy during spinal surgery: a multivariate analysis for risk factors. Spine (Phila Pa 1976) 2014;39:E1339-45. Williams BJ, Sansur CA, Smith JS, et al. Incidence of unintended durotomy in spine surgery based on 108,478 cases. Neurosurgery 2011;68:117-23; discussion 23-4. Buck JS, Yoon ST. The Incidence of Durotomy and its Clinical and Economic Impact in Primary, Short-segment Lumbar Fusion: An Analysis of 17,232 Cases. Spine (Phila Pa 1976) 2015;40:1444-50.

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