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  • Thermal Dynamics, Volumetrics and Seizure Outcomes Following Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) in Pediatric Lesional Epilepsy

    Final Number:

    Kelsey Diva Cobourn BS; Islam Fayed MD MS; Shannon Sullivan BS; Chima Oluigbo MD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting

    Introduction: MRgLITT has emerged as a safe and effective minimally-invasive technique for several intracranial pathologies. However, the effects of variable thermal energy on tissue ablation dynamics are poorly understood, particularly in the pediatric population. This study aims to examine the relationship between energy and volume of ablation in children undergoing MRgLITT for drug-resistant lesional epilepsy, define any correlation between volume ablated and seizure control outcome and any disparities between underlying epileptogenic pathologic substrates.

    Methods: Single-center retrospective review of lesional epilepsy patients undergoing MRgLITT was performed. Volumes were measured by two raters using post-ablation T1-weighted MRI in Osirix. Inter-rater variability was analyzed via ANOVA. Linear regression analysis was performed to determine the relationship of energy to ablated volume. Fisher’s exact test was used to assess independence of seizure outcome by Engel Scale from pathologic substrate or ablated volume >1.5cm3.

    Results: Thirteen patients had twenty total lesions ablated. Substrates included tuberous sclerosis, focal cortical dysplasia, hypothalamic hamartomas, periventricular nodular hyperplasia and mesial temporal sclerosis. Outcomes were documented to mean follow-up of 10 months. Postoperative seizure control outcome was Engel-I in nine (69.2%), Engel-II in two (15.4%) and Engel-III in two (15.4%) patients. Linear regression was calculated to predict the effect of energy on volume of ablation (p=6.47E-6, R=.841). Linear correlation between energy and volume was found to be strongest in tuberous sclerosis lesions (R=.88) and weakest in cortical dysplasia (R=.057). Inter-rater differences were insignificant (p=.73). There was no significant relationship between pathological substrate or volume of ablation >1.5 cm3 and seizure control by Fisher’s Exact Test (p=.67; p=.73).

    Conclusions: We characterized a linear relationship between the in-vivo application of thermal energy and ablated volume. The strength of this correlation was variable across different substrates, but pathologic substrate did not predict seizure outcome. More study is needed in larger populations before these relationships can be fully understood.

    Patient Care: As minimally invasive functional techniques become an increasingly common component of the neurosurgical armamentarium, it is critical to build a better understanding of their effects on both a large scale and at the tissue-level. This study adds to very limited data characterizing the effects of variable thermal energy delivered via MRgLITT on tissue ablation dynamics in the brain. To our knowledge, it is the first to examine this relationship in the pediatric population and to correlate these measures with outcome data. Further investigation will ultimately benefit patient care by allowing for safer and more nuanced application of these new techniques and technologies.

    Learning Objectives: By the conclusion of this session, participants should be able to: 1) Understand the effect of variable thermal energy on the volume of ablation in the pediatric brain 2) Characterize the disparate effects of variable thermal energy on various underlying pathological substrates 3) Discuss whether seizure control outcomes are related to the pathology or volume of tissue ablated


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