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  • Integrated Interbody Fusion in Multi-level Cervical Constructs in Clinical Practice

    Final Number:
    4031

    Authors:
    Jason E. Garber MD

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2018 Annual Meeting - Late Breaking Science

    Introduction: Although extremely effective at a single level, anterior cervical discectomy and fusion (ACDF) with an anterior cervical plate (ACP) for a multilevel construct can be associated with a number of peri- and postoperative complications. Alternatively, and quite possibly superior to cervical plating, cervical integrated interbody fusions with subsequent compressive/lag fixation, has emerged as a promising alternative: smaller exposure, zero-anterior profile, individual, but multilevel-specific sagittal realignment. Objectives: Retrospectively to evaluate patients treated from single-to-multiple levels with integrated interbody fusion.

    Methods: 203 patients (53.4±10.7years) with symptomatic degenerative disc disease with radiculopathy and/or myelopathy were treated with a cervical integrated interbody fusion device with compressive fixation. Patients were assessed pre- and post-operatively at 6 weeks,3,6,12,24 months and evaluated for patient-derived outcome measures, radiographic parameters (effect on device-level lordosis, overall cervical sagittal alignment, fusion status), and device-related complications.

    Results: 74 patients underwent the procedure at single level, 68 at 2-levels, 39 at 3-levels, 17 at 4-levels, 4 at 5-levels, and 1 at 6-levels. No intra-operative complications were recorded. Radiographic results showed lordosis was maintained in the global spine and bone formation was present in the inner column of the device. Overall fusion rate was 92%. The revision surgery patients showed better alignment than pre-operatively with static plates. There were no signs of heterotopic ossification of the ligaments/vertebral bodies. There were no device failures. 86% of patients were able to return to the same level of work as prior to surgery.

    Conclusions: Integrated interbody fusion with compressive/lag fixation appears to be a viable alternative. Previously, studies with static integrated interbody fixation devices have not reported as well as ACP with regards to fusion and clinical outcomes. The benefit of lag-design to provide better fixation and more accurate lordotic curve maintenance of the cervical spine was seen in our series. The opportunity to either revise a previous ACDF with ACP or add to a pre-existing ACDF offers greater flexibility to treat the index level pathology rather than global construct approach.

    Patient Care: Integrated interbody fusion with compressive/lag fixation appears to be a viable alternative to plated ACDF

    Learning Objectives: Integrated interbody fusion with compressive/lag fixation appears to be a viable alternative. Previously, studies with static integrated interbody fixation devices have not reported as well as ACP with regards to fusion and clinical outcomes. The benefit of lag-design to provide better fixation and more accurate lordotic curve maintenance of the cervical spine was seen in our series. The opportunity to either revise a previous ACDF with ACP or add to a pre-existing ACDF offers greater flexibility to treat the index level pathology rather than global construct approach.

    References:

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