In gratitude of the loyal support of our members, the CNS is offering complimentary 2021 Annual Meeting registration to all members! Learn more.

  • Compare the Hemorrhagic Complication Rate After Intraarterial Thrombolysis with Stent Retrievers Weather tPA Infusion or Not

    Final Number:
    1333

    Authors:
    Do-Sung Yoo MD PhD; Han-Yong Huh; Jae-Geun Ahn; Cheol Ji

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2017 Annual Meeting

    Introduction: Intraarterial thrombolytic therapy (IA-Tx) with stent retriever is accepted as an additional treatment for selected patients. But hemorrhagic complication rate weather intravenous tissue plasminogen administration or not before the IA-Tx with Solitaire device, is not reported yet. Authors tried to find the clinical outcomes according to the IV-tPA before the IA-Tx and perfusion diffusion mismatching (P/D-mismatching).

    Methods: Eighty-one treated IA-Tx with the Solitaire device, diagnosed as anterior circulation larger vessel occlusion were included in this study. CT-angiography was done as an initial diagnostic image and acute stroke MR imaging followed after the IV-tPA. 42 patients were in the tPA group and 39 patients were in the non-tPA group. Recanalization rate, clinically significant hemorrhagic (sICH) and clinical outcomes were recorded according to weather IV-tPA or not.

    Results: Recanalization rate was 81.0% in IV-tPA group, and it was 69.2% in non-tPA group (p=0.017). While sICH were 19.9% and 25.6% respectively (p=0.328). Neurologic outcomes also did not influence by tPA infusion or not. But according to the P/D-mismatching or not, the recanalization rate and sICH were 91.9% and 16.7% in the mismatched group and 46.7% and 46.7% in the matched group (p=0.008 & p=0.019, respectively).

    Conclusions: For patients treated with IA-Tx with stent retriever, weather IV-tPA influence or not did not influence on the sICH, recanalization rate and neurologic outcomes. While P/D-mismatching or not was correlated well with sICH, recanalization rate and clinical outcomes.

    Patient Care: Fine technical improvement in thrombolysis with stent device.

    Learning Objectives: Major vessel occusion patients management by mechanical thrombolysis.

    References:

We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy