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  • Comparison of Predictive Grading Systems for Procedural Risk in Endovascular Treatment of Brain Arteriovenous Malformations – Analysis of 104 Consecutive Patients

    Final Number:

    Benjamin Pulli MD; Christopher J Stapleton MD; Matthew Koch MD; Aman B. Patel MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2017 Annual Meeting

    Introduction: Endovascular embolization of brain arteriovenous malformations (AVMs) is widely utilized, often used in conjunction with micro- and/or radiosurgery. Grading systems to assess procedural risks of endovascular embolization have been proposed, but none has been independently validated. We sought to validate and compare these grading systems in 104 consecutive patients with brain AVMs who underwent endovascular embolization between 2003 and 2016 at our tertiary academic referral center.

    Methods: Clinical and demographic data were obtained from the medical records. Cerebral angiograms were reviewed and Buffalo[1], AVM Neuroendovascular (AVMN)[2], and Spetzler-Martin (SM) grades determined. Clinical outcomes and complications were collected. Receiver operating characteristics (ROC) curve analysis was performed.

    Results: Forty-five(43.3%) patients were females, with an average age at presentation of 43.2±16.2 years. Forty-nine patients (47.1%) presented with hemorrhage. Fifty-five (52.9%) AVMs were located on the left side, 40 (38.5%) were in an eloquent brain region, and mean AVM size was 3.4±1.4 cm. There were 10 major and 17 minor complications in 25 patients (vessel rupture: 9; retained/fractured microcatheter: 5; off-target embolization: 4; extension of embolic cast into venous outflow: 2; artery dissection: 1; ischemic stroke presumed to be related to embolization: 6). Arterial pedicle size (p=0.002) and number of arterial pedicles (p=0.04) were predictors of complications, while AVM side, location in/near an eloquent brain region, patient age, AVM size, or venous drainage pattern were not. The Buffalo score was predictive of complications (p=0.004), but AVMN (p=0.23) and SM grades (p=0.35) were not (A). ROC curve analysis revealed an area under the curve (AUC) of 0.68±0.05 for the Buffalo score, significantly better than AVMN (AUC 0.58±0.06, p=0.04) and SM grades (AUC 0.56±0.06, p=0.05, B).

    Conclusions: Our independent analysis of 104 patients with brain AVMs treated with endovascular embolization validates the predictive capacity of the Buffalo score, but not AVMN or SM grades, for endovascular embolization procedural risk.

    Patient Care: The results from this analysis independently validate the Buffalo score but not the AVMN or SM grades to predict procedural risk of endovascular brain AVM embolization. This will allow for better stratification of brain AVM patients by procedural risk, and will ultimately result in safer care for these patients.

    Learning Objectives: By the conclusion of this session, participants should be able to: 1) describe the published grading systems for procedural risk of endovascular embolization of brain AVMs , 2) identify the most important brain AVM characteristics that determine embolization risk, and 3) list the most common complications of endovascular embolization and their relative frequencies.

    References: [1] Dumont TM et al. A proposed grading system for endovascular treatment of cerebral arteriovenous malformations: Buffalo score. Surgical Neurology International 2015, 6:3. [2] Feliciano CE et al. A Proposal for a New Arteriovenous Malformation Grading Scale for Neuroendovascular Procedures and Literature Review. P R Health Sci J. 2010, 29:2.

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