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  • Outcomes Following Exploratory Burr Holes for Traumatic Brain Injury in a Resource-Poor Setting

    Final Number:

    Jessica C Eaton BA; Asma Bilal Hanif MS; Gift Mulima MBBS, FCS-ECSA; Chifundo Kajombo MBBS, FCS-ECSA; Anthony Charles MD, MPH

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2017 Annual Meeting

    Introduction: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Low- and middle-income countries (LMICs) suffer from a high incidence of and mortality from TBI. Computed tomography (CT) scan is the diagnostic method of choice, but is often inaccessible in LMICs, where exploratory burr holes (EBH) remain a necessary diagnostic and therapeutic procedure. We sought to describe indications and outcomes of patients undergoing EBH at our sub-Saharan African tertiary care center.

    Methods: We performed a retrospective review of prospectively collected data at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi. All trauma patients presenting between June 2012 and July 2015 with a deteriorating level of consciousness and localizing signs who underwent EBH were included. Additionally, we included all patients admitted with TBI, requiring higher-level care during 2011. Because there was no neurosurgeon on staff in 2011, no patients underwent EBH. We performed logistic regression to identify predictors of mortality in the total population of TBI patients.

    Results: 241 patients presented to KCH with TBI requiring higher-level care, with a total mortality of 16.4% (Table 1). 163 (68%) underwent EBH. Of patients that underwent EBH, 87.6% of patients had intraoperative findings, with subdural hematoma being the most common (51.2%). Mortality in patients who underwent EBH was 6.8%. In surviving patients who underwent exploratory burr hole, 71.1% had a favorable outcome, defined as good recovery or moderate disability on the Glasgow Outcome Scale. Mortality in patients that did not undergo EBH was 43.9%. Upon logistic regression adjusted for age, sex, and Glasgow Coma Score (Table 2), not undergoing EBH significantly increased the odds of mortality (OR=12.0, p=0.000, 95% CI=4.48-31.9).

    Conclusions: EBH remain an important diagnostic and therapeutic procedure for TBI in LMICs. In low-resource settings, EBH technique should be incorporated into general surgery education to attenuate TBI-related mortality.

    Patient Care: We have demonstrated that morbidity and mortality is markedly reduced when exploratory burr holes are performed on patients with moderate to severe TBI in one low-resource setting. We hope morbidity and mortality can be likewise reduced in other low-resource settings by training local general surgeons in this technique.

    Learning Objectives: By the conclusion of this session, participants should be able to 1. Understand the global burden of TBI and the disproportionate incidence and rate of mortality in low-income countries 2. Identify predictors of mortality among TBI patients in one sub-Saharan African tertiary care center 3. Consider the benefits and disadvantages of incorporating exploratory burr holes into surgical education in low-income settings.

    References: 1.Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1459-544. Ramirez SS, Hyder AA, Herbert HK, Stevens K. Unintentional injuries: magnitude, prevention, and control. Annu Rev Public Health 2012;33:175-91. 3.Capone-Neto A, Rizoli SB. Linking the chain of survival: trauma as a traditional role model for multisystem trauma and brain injury. Curr Opin Crit Care 2009;15:290-4. 4.Houseman CM BS, Narayan RK. Closed Head Injury. In: Ellenbogen RG AS, Sekhar LN, ed. Principles of Neurosurgery. 3rd ed. Philadelphia: W.B. Saunders; 2012:325-247.

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