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  • An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

    Final Number:

    Grace Collord; Patrick Tarpey; Ramez W. Kirollos FRCS; Michael William McDermott; Zvi Ram; Chris Mcmurran; Sam Behjati; Imran Noorani MD MRCS; Kieren Allinson; V. Peter Collins; Rasheed Zakaria; Adam MH Young MB BChir, MRCS; Gabriele Schackert; Matthias Kirsch; Mike Jenkinson; Manel Esteller; Ultan McDermott; Thomas Santarius MD, PhD, FRCS

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2017 Annual Meeting - Late Breaking Science

    Introduction: Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes.

    Methods: Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent cohort of 50 anaplastic meningiomas.

    Results: A key finding was the delineation of two distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup.

    Conclusions: Our analyses of the largest cohort of anaplastic meningiomas to date discern two biologically distinct variants of anaplastic meningioma with potential prognostic and therapeutic significance.

    Patient Care: The results of this study will enable better prognostic and therapeutic stratification of patients with anaplastic meningiomas.

    Learning Objectives: Histologically diagnosed anapaestic meningiomas comprise of two biologically distinct gripes with very different prognosis.


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