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  • Repair of Large Dural Defects Utilizing Non-Biologic Resorbable Dura Substitute

    Final Number:

    Matthew R MacEwan BSE, PhD; Zohny Zohny MD; Tamas Kovacs; Wilson Zachary Ray MD

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2016 Annual Meeting

    Introduction: Resorbable, non-biologic dura substitutes offer the ability to immediately seal dural defects and progressively resorb following effective neoduralization and defect repair. Yet, few studies have demonstrated whether fully-resorbable dura substitutes are optimally suited for repair of large dural defects. The present study was conducted to evaluate the comparative efficacy of resorbable, non-biologic dura substitutes in the repair of dural defects of varying size in a canine duraplasty model.

    Methods: Small (1.6cm2) and large (4.0cm2) dural defects were created bilaterally and repaired with a fully-resorbable, non-biologic dura substitute (Cerafix® Dura Substitute). Animals were observed for signs of CSF leakage or neurological abnormalities and repair sites were excised either 4 or 13 weeks after surgery to evaluation local tissue reaction and neoduralization.

    Results: Both small and large defects were effectively repaired with no evidence of CSF leakage or neurological sequalae in either group. Histological analysis of repair sites revealed comparable rates of tissue healing and vascularization in small and large defects at both 4 and 13 weeks, and that gradual resorption of the graft was balanced by progressive neoduralization over time. Upon conclusion of the study at 13 weeks, all dural defects were fully healed with complete neoduralization of the repair site.

    Conclusions: Efficacy of fully-resorbable, non-biologic dural substitute appears to be independent of the size of induced dural defects. Furthermore, timed resorbtion of non-biologic grafts was effectively balanced by increasing neoduralization to achieve successful defect closure in all repair sites.

    Patient Care: Watertight closure of dural defects remains a critical component of many routine neurosurgical procedures and key to rapid patient recovery. An emergence of a new class of non-biologic and resorbable dural graft materials has raised new questions as to appropriate use and potential benefits and limitations of these materials. The present study is designed to provide clinicals with added insight into the many considersations that should be taken into account when utilizing these materials, and further to evaluate the potential efficacy of utilizing resorbable graft materials in the repair of various size dural defects.

    Learning Objectives: By the conclusion of this session, participants should be able to: 1) Describe the intra-operative and post-operative impact of dura substitute graft composition (biologic, non-biologic, etc.), 2) Discuss the importance of matching dura substitue materials to the properties of target defects, and 3) Understand the limitations and benefits of emerging resorbable, non-biologic graft materials


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