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  • Surgical Treatment of Unruptured Aneurysms: 10 Year Single Surgeon Experience at University of Cincinnati Medical Center

    Final Number:
    1134

    Authors:
    Jennifer Kosty BA MD; Yair M. Gozal MD, PhD; Bryan Matthew Krueger MD; Mario Zuccarello MD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2016 Annual Meeting

    Introduction: The International Study of Unruptured Intracranial Aneurysms (ISUIA) reported a 12.6% morbidity and mortality rate at 1 year for surgical intervention of unruptured intracranial aneurysms (UIAs). This was higher than the 5 year rupture rate for anterior circulation aneurysms <12 mm and posterior circulation aneurysms <7 mm (1). These findings have been used as an argument against the surgical treatment of these aneurysms. Several groups have demonstrated better surgical outcomes for aneurysms in high versus low volume centers (2,3). We therefore reviewed the experience of a single high-volume surgeon in the treatment of UIAs.

    Methods: The medical records of all patients who underwent microsurgery for an UIA from July 2005 to July 2015 at our institution by a single surgeon were reviewed. Baseline demographics and aneurysm characteristics were reviewed. Outcomes included discharge disposition, hospital length of stay, complications, surgery-related death, and post-operative mRS of 3-5 at 30 days, 1 year and last follow-up.

    Results: During the reviewed period, 447 UIAs in 395 patients were identified. The average age was 63.2 years, and 58% were females, 42% were males. The average aneurysm size was 9.3 mm. Twenty-eight percent of patients had multiple aneurysms, and 17% had multiple aneurysms clipped at the same time. The average length of hospital stay was 3.3 days. 96% of patients were discharged to home. No surgery-related deaths were reported. New post-operative cranial nerve deficits were noted in 7% of patients, but persisted at last follow-up in only 1.5%. A post-operative mRS of 3-5 was noted in approximately 1.3% of patients at last follow-up.

    Conclusions: The surgical morbidity and mortality related to the treatment of UIAs may differ between surgeons and institutions. Some individuals may have better outcomes than what have been previously published in large, multi-center trials.

    Patient Care: This study suggests that the anticipated neurological morbidity and mortality related to the surgical treatment of unruptured intracranial aneurysms is provider-specific and may be much lower than rates provided by multi-institutional studies. Indeed, for aneurysms between 7 and 12 mm in size, surgical morbidity may also be lower than what is anticipated for the natural history of the lesion.

    Learning Objectives: By the conclusion of this session, participants should be able to 1) Describe the indications for microsurgical treatment of unruptured intracranial aneurysms. 2) Describe the most common complications associated with microsurgery for unruptured intracranial aneurysms 3) Consider the effect of surgical training and surgeon volume on the surgical treatment of unruptured aneurysms

    References: 1. Wiebers DO, Whisnant JP, Huston J, 3rd, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003;362:103-10. 2. Zacharia BE, Bruce SS, Carpenter AM, et al. Variability in outcome after elective cerebral aneurysm repair in high-volume academic medical centers. Stroke 2014;45:1447-52. 3. Berman MF, Solomon RA, Mayer SA, Johnston SC, Yung PP. Impact of hospital-related factors on outcome after treatment of cerebral aneurysms. Stroke 2003;34:2200-7.

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