Skip to main content
  • Atypical and Anaplastic Meningioma (AAM): Outcomes in a Population-Based Study

    Final Number:

    Tomas Garzon-Muvdi MD MS; Wuyang Yang MD MS; Michael Lim MD; Henry Brem MD; Judy Huang MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2016 Annual Meeting

    Introduction: Approximately 5% of meningiomas are atypical and anaplastic (AAM)(WHO II and III). AAM are aggressive tumors and are coupled to a poor prognosis and higher mortality caused by the tumor. We performed a population-based study to identify important factors that determine survival of patients with AAM.

    Methods: We used data from patients with AAM from the SEER dataset between 1973-2012. Basic demographics, size of the tumor, tumor location, and treatment variables were included for each patient. Provided with the relatively older population and benign disease course, we observed a significant portion of patients with unrelated death; therefore, a competing risk analysis was employed to account for unrelated deaths when delineating factors associated with cumulative incidence of tumor-related deaths, cumulative incidence of tumor-related death was computed for each factor in a multivariate competing risk regression model.

    Results: We identified 522 patients after applying inclusion and exclusion criteria. Mean age at diagnosis for all patients was 60.8 ± 15.7 years. Seventy-three percent of patients were white, 15.5% black, and 9.8% were Asian. More than half of the patients (53.8 %) were married. Mean tumor size was 48.2 ± 20.3 mm. The vast majority (94.8%) of tumors were supratentorial. Significant factors affecting survival of patients diagnosed with AAM were identified in a multivariate proportional competing risk regression analysis: older age (HR:1.03,CI=[1.01,1.04],p<0.001), infratentorial location (HR:2.81,CI=[1.20, 6.56],p=0.017), tumor size (HR 1.01, CI=[1.00, 1.02],p=0.032), and radiation treatment (HR:1.52, CI=[1.11,2.09], p=0.01).

    Conclusions: Older age, infratentorial location, tumor size, and radiation treatment were associated with tumor-related death of atypical meningioma.

    Patient Care: This population-based study examines atypical/malignant meningiomas, which is an extremely rare disease with unknown disease progression and management strategy. We found several factors associated with tumor-related death of these patients. In addition, we found that radiation provided no survival benefit in tumor-related death. This study may serve as the foundation of knowledge on this rare disease.

    Learning Objectives: By the conclusion of this session, participants should be able to: 1) To utilize large population-based datasets to improve understanding of the outcome of patients with atypical and anaplastic meningioma. 2) To identify variables that determine survival of atypical and anaplastic meningioma patients.


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy