Introduction: The volume of intracerebral hemorrhage (ICH) measured at hospital admission is the strongest predictor of clinical outcome in ICH. Despite the high incidence rate of ICH in Asian, there was relative absence of data regarding predictors of ICH volume in Asians. The purpose of the present study was to determine predictors of deep ICH volume and the effect of predictors on the short term mortality in Asians.

Methods: Hematoma volume was measured using the ABC/2 method. ICH volume was transformed to the natural log to normalize distributions for all analyses. We estimated the coefficients of ICH volume based on relevant predictors using multivariable linear regression. We also determined the association between body mass index and ICH volume using a regression line and a line determined by a locally weighted scatter plot smoothing.

Results: A total of 1039 consecutive patients with primary spontaneous supratentorial deep ICH were enrolled in this study over a 12-year period from two twin hospitals in Korea. The median ICH volume was 19.7 mL. The average patient age was 59.2 years, and 62.4% of patients were men. The mean ICH volume showed a gradual, approximately 2% decrease per one body mass index increase in the current study, after adjusting for all relevant variables. (ß=-0.024; standard error (SE)=0.004; P<0.001).Relative to overweight patients, there was a 47%, 11%, and 18% increase in admission mean ICH volume in underweight, normal weight and obese patients, respectively. Patients in the first quartile and underweight BMI groups had 1.45-fold (HR,1.45; 95% CI, 1.03 to 2.03; P=0.035) and 1.77-fold higher increased risk of death during the first 3 months after ICH, retrospectively.

Conclusions: We demonstrated the association between various predictors and admission ICH volume and short term mortality in Asians. Further studies are needed to account for these observations and determine their underlying mechanisms.

Patient Care: If we find out the predictors of ICH volume, we able to educate patients with high risk for increasing ICH volume.

Learning Objectives: By the conclusion of this session, participants should be able to determine predictors of deep ICH volume and the effect of predictors on the short term mortality in Asians.

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