Skip to main content
  • Understanding Volume-outcome Relationship in Severe Traumatic Brain Injury

    Final Number:

    Aziz S. Alali MD PhD; David Gomez MD; Victroia McCredie MBChB; Todd Graham Mainprize MD; Avery B. Nathens MD, MPH, PhD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2016 Annual Meeting - Late Breaking Science

    Introduction: Volume-outcome relationship in severe traumatic brain injury (TBI) population remains unclear. We examined the relationship between volume of severe TBI patients per hospital and in-hospital mortality, major complications, and mortality following a major complication (i.e. failure to rescue).

    Methods: In a multicenter cohort study, data on 9,255 adults with severe TBI were derived from 111 hospitals participating in the American College of Surgeons Trauma Quality Improvement Program over 2009-2011. Hospitals were ranked into quartiles based on their volume of severe TBI during the study period. Hierarchical models were used to examine the association between hospital quartile of severe TBI volume and in-hospital mortality, major in-hospital complications and mortality following a major complication after adjusting for patient and hospital characteristics. A major complication was defined as a cardiovascular event (cardiac arrest with cardiopulmonary resuscitation, myocardial infarction or cerebrovascular accident), acute respiratory distress syndrome, pneumonia, sepsis or acute kidney injury requiring dialysis. In sensitivity analyses, we examined these associations after excluding transferred cases.

    Results: Overall mortality was 37.2% (n=3,447). 2,098 patients (22.7%) suffered from one or more major complication. Among patients with major complications, 27.8% (n=583) died. Compared to the quartile with the lowest volume (quartile 1), the adjusted odds ratio of death after severe TBI was 0.54 [95% confidence interval (CI): 0.33-0.88] for quartile 4, 0.62 (95% CI: 0.37-1.04) for quartile 3 and 0.81 (95% CI: 0.48-1.39) for quartile 2. However, there was no significant association between the hospital volume quartile and the odds of a major complication or the odds of death following a major complication in adjusted analyses (Figure 1). After excluding transferred cases, similar results were found.

    Conclusions: High-volume hospitals were associated with lower in-hospital mortality following severe TBI. However, this mortality reduction was not associated with lower risk of major complications or death following a major complication.

    Patient Care: Understanding the underlying mechanisms of overall mortality disparity between high- and low-volume hospitals can help devise quality-improvement strategies for low-volume centers to optimize care for TBI patients that cannot be safely transferred to higher-volume centers. Future research on volume-outcome relationship in severe TBI should focus on potential mechanisms that were not examined in our study.

    Learning Objectives: 1. High-volume hospitals is associated with lower hospital mortality following severe TBI. 2. This mortality reduction cannot be explained by differences in rate of major complications or failure to rescue following a major complications.


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy