In gratitude of the loyal support of our members, the CNS is offering complimentary 2021 Annual Meeting registration to all members! Learn more.

  • Astrocytic Brain Tumors in a Sub-Saharan African Population: Is the Relationship Between Location and Outcome an Age Dependent Prognostic Paradigm?

    Final Number:
    440

    Authors:
    Enoch Ogbonnaya Uche MBBS

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: Although astrocytomas are the most common primary brain tumors worldwide, they are still poorly reported in our environment.Moreso, clincal outcome determinants have been poorly investigated in our subregion

    Methods: We prospectively studied adult patients with astrocytic tumors in 3 tertiary hospitals within southeast Nigeria over a 5 year period. Patients’ clinical data as well as radiology and histology reports were analyzed. Follow- up interval was 3months to 4.5 years. Data analysis was performed using SPSS version 17 with evaluation of confidence limits, Chi Square tests at the 95% level of significance

    Results: Of 61 patients with neuroimaging features of brain astrocytoma , while 46 patients had histological confirmation. Mean age was 43.4±1.7 years (95% CI), low grade tumors- 35.3±0.9years (95%CI), high grade tumor patients - 49.6±0.4 years (95%CI). 37 patients were male and 24 were female with M:F ratio of 1.5. Major complaints were headache and seizures in 70.5 %( 43 patients) and 58.3 %( 35 patients) respectively, Duration of symptoms was 2 months to 17 months with a mean of 9.6±1.7 (95%CI) months. 41 cases were supratentorial, 17 cases were infratentorial, while 3 cases were transtentorial. 33patients had microsurgical resections, 11 had biopsy only, while 31 had CSF diversion.13 patients had low grade tumors (WHO grades I and II) , while 36 patients were high grade(WHO grades III and IV). Survival rates after 1year and 3 years follow up were 77% and 61% for low grade tumors and 27% and 8.3% for high grade tumors. Tumors in the supratentorial compartment in patients below 45 years were associated with longer survival across the tumor grades (X2=7.9, df =1, p<0.05). Infratentorial location was associated with poor overall outcome as well as shorter progression free survival in patients below 45 years with high grade tumors (X2=5.7, df=1,p<0.05)

    Conclusions: Supratentorial location is associated with better survival among younger adults with astrocytomas regardless of grade.

    Patient Care: treatment planning and prognostication

    Learning Objectives: The location of an astrocytoma and age significantly influence outcome and should be important consideration in clinical prognostication

    References:

We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy