• Gamma Knife Stereotactic Radiosurgery for Vestibular Schwannomas in Elderly Patients

    Final Number:

    Justin Tay BS; Philip Lee MD PhD; Ajay Niranjan MD, MBA; Hideyuki Kano MD, PhD; L. Dade Lunsford MD; Edward A. Monaco III MD, PhD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: The role of stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) in the elderly population (>80 years) remains controversial. SRS may be the best strategy in such patients who often have numerous comorbidities.

    Methods: Sixty-two VS patients underwent Gamma Knife SRS between 1988 and 2012. Three patients had previous incomplete surgical resection. The median tumor volume was 3.7 cc. All patients received a median margin dose of 13 Gy (range 12-14 in a single procedure). The median age was 82 years (range, 80-95) and the median follow-up was 24 months (range, 4-91 months). Overall survival, tumor response, adverse radiation effects and clinical outcomes were evaluated.

    Results: Overall median survival of these patients was 79.4 months (range, 5-228 months) following SRS. Thirty-nine patients had serial follow up magnetic resonance imaging (MRI). Seventeen patients experienced tumor stability, two had transient growth followed by volumetric stabilization. Nineteen demonstrated tumor regression. One patient required post-GK surgical resection and another stereotactic cyst drainage. Three patients underwent CSF diversion because of progressive symptomatic hydrocephalus. Three patients experienced new facial neuropathy and three patients developed trigeminal neuropathy after SRS. No patient suffered an adverse radiation effect. Of the three patients who had serviceable hearing (Gardner-Robertson < 2) before SRS, one patient worsened and two were unchanged. One patient’s hearing improved (grade 3 to grade 2).

    Conclusions: Elderly patients with VS may have extended additional life spans. SRS provides a low risk strategy that results in tumor control and functional preservation. It is the procedure of choice for such patients and stabilizes or improves quality of life.

    Patient Care: The work emphasizes the importance of an individualized, patient centered approach, the goal of which is to yield tumor control and avoid risks.

    Learning Objectives: By conclusion of this session, participate should be able to: 1) Discuss the role of SRS in the treatment of elderly patients harboring vestibular schwannomas and, 2) Describe the benefits and drawbacks of SRS for these patients.


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy