Skip to main content
  • Systematic Review of Seizure Freedom Rates after Surgical Resection of Dysembryoplastic Neuroepithelial Tumors

    Final Number:

    Phillip A Bonney BS; Lillian B Boettcher BA; Chad A Glenn MD; Andrew K.P. Conner MD; Adam Smitherman; Michael Edward Sughrue MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: Dysembryoplastic neuroepithelial tumors present with seizures in the majority of cases. We report the results of a systematic review of seizure freedom rates following resection of these benign lesions.

    Methods: We searched the English literature using PubMed for articles presenting seizure freedom rates for dysembryoplastic neuroepithelial tumors as a unique entity. Patient demographics, tumor characteristics, and operative variables were assessed across selected studies.

    Results: Twenty-eight articles were included in the analysis. Median age at surgery across studies was 16 years (range: 6 - 31 years). Median duration of epilepsy pre-operatively was 4 years (range: 0.5 - 18 years). Pre-operative seizure resistance to anti-epileptic drug therapy was rarely reported in systematic fashion. Median gross-total resection rate across studies was 80% (interquartile range: 64% - 94%). Authors variously chose lesionectomy or extended lesionectomy operations within and across studies. Median seizure freedom rate was 85% (interquartile range: 73% - 92%), with only two studies reporting less than 60% of patients seizure free. Seizure outcomes were either reported at one year of follow-up or at last follow-up, which had a median of 4 years (range: 2 - 10 years). In most studies, more than half patients who were seizure free remained on at least one AED. Greater extent of resection was associated with seizure freedom in four studies.

    Conclusions: In all but one study, the majority of patients were seizure free after surgical resection. The interquartile range for seizure freedom is 73% - 92% across studies. The extent of resection is likely an important factor in seizure freedom. Most patients remained on anti-epileptic drugs post-operatively.

    Patient Care: This will improve our understanding of outcomes after resection of DNETs to better educate patients pre-operatively.

    Learning Objectives: By the conclusion of this session, participants should be able to: (1) Cite the approximate seizure freedom rate after surgical resection of dysembryoplastic neuroepithelial tumors, (2) Relate that most patients will achieve freedom from seizures, but will likely not be weaned from anti-epileptic drugs postoperatively.


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy