Introduction: Gliomas are a group of heterogeneous primary central nervous system (CNS) tumors arising from the glial cells. Malignant gliomas account for a majority of malignant primary CNS tumors and are associated with high morbidity and mortality. Glioblastoma is the most frequent and malignant glioma, and despite the recent advances in diagnosis and new treatment options, its prognosis remains dismal.
New opportunities for the development of effective therapies for malignant gliomas are urgently needed.
Microwave Ablation (MW) is a technique used from other field since 2005 in liver,tiroid tumor with good results.
Methods: Nine cases are described with Glial Brain tumors ,Two Astrocytoms and Seven Glioblastoma Multiforme(GBM). Treated with Microwave Ablation during convencional surgery. All cases the tumor was localized with image guidance by using Trans-operative Ultrasound Aloka 5500. A thin (14.5-gauge)antenna .(MEDWAVES ) and energy was applied for 3 minutes until the temperature sensor at proximal position of the 4-cm antenna reached 70-90°Celcius
The cortical brain surface temperature registered 32 to 34 degrees Celsius during the ablation process.
Cavitation and ablation was observed, and adjacent vascular and brain structures were preserved, visualized by surgical microscope and Doppler ultrasound Trans-operative.
Complete resection was performed with conventional micro-techniques.
Histopathological results of Astrocytoms and Glioblastoma Multiforme were confirmed.
Conventional Radiotherapy and Chemotherapy was aplied in GBM cases.
Post-operative clinical results were analyzed.
Results: The Aplication of MW Ablation Intratumoral during
surgery in GBM was Safe, in All Cases no aditional neurological deficit was detected.
The Brain temperature arroud of the tumor was 32 to 34 Celsius grades.
The intratumoral vascular flow was decreased,and the tumor was more easy removed.
Conclusions: 1.-Microwave Ablation is excellent tool for Glial Tumors Surgery
2- Was safe in all cases
3.-Decrease Intratumoral Blood Flow , Therefore enable the microsurgical resection.
Patient Care: .- Facilitates the microsurgical resection of glioma Tumors
.-Decrease the time surgery, and Bleeding .
Learning Objectives: The participants should be able to understand the new aplication tehcnique for surgery of the Glial Tumor
References: 1. Microwave ablation: principles and aplications
Simon CJ1, Dupuy DE,Mayo-smith ww
Radiographics 2005 oct:25 Suppl 1:S69-83
2.-Microwave Tissue Ablation: Biuophysics, Technology and Applications
Christopher L. Brace, PhD
Crit Rev Biomed Eng 2010, 38(1) 65-78