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  • Comparison of Deferoxamine and Methylprednisolone Protective Effect of Pharmacological Agents on Lipid Peroxidation in Spinal Cord Injury in Rats

    Final Number:
    488

    Authors:
    Cem Dinc; A.Celal Iplikcioglu; Cem Atabey; Ahmet Eroglu; Kivanc Topuz; Osman Ipcioglu; Dilaver Demirel

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: To investigate the protective effect of deferoxamine (DFO) administration in comparison with methylprednisolone (MP) on lipid peroxidation and antioxidants after spinal cord injury (SCI) in rats.

    Methods: Forty Wistar rats were randomly divided into 5 groups as sham laminectomy (n = 8), laminectomy with SCI (n = 8), laminectomy with SCI and 0.9% saline intraperitoneal (i.p.) (n = 8), laminectomy with SCI and 30 mg/kg MP i.p. (n = 8), and laminectomy with SCI and 30 mg/kg DFO i.p. (n = 8). Neurological defi cits were examined 24 hours after trauma, and all rats were killed. Spinal cord segments were harvested for both biochemical and histopathological evaluation.

    Results: At 24 hours post-SCI, whereas malondialdehyde levels were increased, superoxide dismutase, catalase, and glutathione peroxidase levels were decreased in groups I, II, and III. MP and DFO treatment decreased MDA levels and increased superoxide dismutase CAT, and glutathione peroxidase levels in control and study groups. There was no statistically signifi cant difference between treatment with MP and DFO ( P > 0.05). All rats were paraplegic after SCI, except in the sham group. Histopathological improvement was observed in control and study groups.

    Conclusions: This study indicates that benefi cial effects may be provided and further studies need to investigate the dose-dependent benefi cial and side effects of DFO in SCI.

    Patient Care: Spinal Cord ─░njury

    Learning Objectives: To investigate the protective effect of deferoxamine (DFO) administration in comparison with methylprednisolone (MP) on lipid peroxidation and antioxidants after spinal cord injury (SCI) in rats.

    References:

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