Introduction: To investigate the protective effect of deferoxamine
(DFO) administration in comparison with methylprednisolone (MP)
on lipid peroxidation and antioxidants after spinal cord injury (SCI)
in rats.
Methods: Forty Wistar rats were randomly divided into 5 groups
as sham laminectomy (n = 8), laminectomy with SCI (n = 8),
laminectomy with SCI and 0.9% saline intraperitoneal (i.p.)
(n = 8), laminectomy with SCI and 30 mg/kg MP i.p. (n = 8), and
laminectomy with SCI and 30 mg/kg DFO i.p. (n = 8). Neurological
defi cits were examined 24 hours after trauma, and all rats were
killed. Spinal cord segments were harvested for both biochemical
and histopathological evaluation.
Results: At 24 hours post-SCI, whereas malondialdehyde levels
were increased, superoxide dismutase, catalase, and glutathione
peroxidase levels were decreased in groups I, II, and III. MP and
DFO treatment decreased MDA levels and increased superoxide
dismutase CAT, and glutathione peroxidase levels in control and
study groups. There was no statistically signifi cant difference
between treatment with MP and DFO ( P > 0.05). All rats were
paraplegic after SCI, except in the sham group. Histopathological
improvement was observed in control and study groups.
Conclusions: This study indicates that benefi cial effects may be
provided and further studies need to investigate the dose-dependent
benefi cial and side effects of DFO in SCI.
Patient Care: Spinal Cord İnjury
Learning Objectives: To investigate the protective effect of deferoxamine
(DFO) administration in comparison with methylprednisolone (MP)
on lipid peroxidation and antioxidants after spinal cord injury (SCI)
in rats.