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  • The Effects of Omeprazole after Traumatic Brain Injury at Rats

    Final Number:

    Rafet Özay MD; Mehmet Erhan Türkoglu MD; Bora Gürer; Habibullah Dolgun; Oya Evirgen; Berrin Imge Ergüder; Nazli Hayirli; Levent Gürses; Zeki Sekerci

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: Trauma causes to primary and secondary injury and, the secondary injury is the most important phase. Most of the researchs on neurotrauma practice are mainly focused on the prevention of secondary injury. The purpose of this study was evaluate, to the effects of high dose omeprazole (Om) after head trauma.

    Methods: In this study, 24 rats were randomized in four groups of six animals (n:6) as follows: group 1 (control), group 2 (trauma), group 3 (methylpredinisolone (MP) 30 mg/kg) and group 4 (Om 20mg/kg). In the control group no trauma was performed. In all the other groups, the head trauma model was created by the a free fall from a height. Following 24 hours all rats were sacrificed. Serum and tissue level of antioxidant panels, lipid peroxidation panels, and Caspase-3 were analyzed. Histopatological evaluation were performed.

    Results: After traumatic brain injury, both the serum levels and tissue levels of the oxidative stress and lipid peroxidation biomarkers (malondialdehyde, nitric oxide, nitric oxide synthase, xanthine oxidase) as well as Caspase-3 were found to be decreased in group 3 and 4 (Om). The levels of antioxidants (superoxide dismutase and glutathione peroxidase) were found to be increased compared to the trauma group in treatment groups (Table-1). Perineural and perivascular edema, satellitosis and spongiosis degrees and pathological scoring results were significantly low in Om and MP groups compared to trauma group (Table-2) (Figure-1,2). The number of degenerating neurons in both treatment groups were determined to be lower than trauma group (Table-3).

    Conclusions: Om is inhibiting to proton pump. Our results revealed for the first time that Om has antioxidant and neuroprotective effects following traumatic brain injury due to its decreasing effect on intracellular acidity.

    Patient Care: Present study will help to prevent from effects of secondary neuronal injury after head trauma; so that it will aid for decreasing the total costs of patient treatment care and secondary injury in traumatic head injuries.

    Learning Objectives: Om exhibits meaningful neuroprotective activity following traumatic brain injury.


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