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  • Opening Eyes Increases High Beta Activity in Human Subthalamic Nucleus Local Field Potentials

    Final Number:
    770

    Authors:
    Lucy Gee; Nita Chen; Brant Lai; Abigail Belasen; Vignessh Kumar; Joannalee C Campbell PhD; Youngwon Youn; Priscilla DeLaCruz; Meghan Wilock; Damian Shin; Adolfo Ramirez-Zamora MD; Julie G. Pilitsis MD, PhD

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: Abnormal beta oscillations (13-30Hz) in the basal ganglia govern motor symptoms of Parkinson’s disease (PD), and studies have shown movement, dopaminergic medication and deep brain stimulation (DBS) can reduce these oscillations in the subthalamic nucleus (STN). Local field potentials (LFPs), used to evaluate neural population activity, are promising for the development of activity dependent neurological tools and closed loop DBS systems, however the impact of routine physiological behavior changes remains unclear. We examine the effects of eye opening on LFP activity in the STN.

    Methods: Intraoperative LFPs were recorded in 10 PD patients undergoing STN DBS surgery. Four 25s blocks were obtained in the STN with eyes open, closed, open with movement, and closed with movement. Post-operatively, spectrograms were made and power spectral density (PSD) analysis was performed on alpha (8-12Hz), low-beta (13–20Hz) and high-beta (21–29Hz).

    Results: High-beta activity increased with eyes open. Furthermore, alpha activity increased with movement in this state. When eyes were closed, passive movement increased beta and alpha activity (Figure 2). Low-beta bands were higher in the left STN than the right when the eyes were open or closed with movement. Additionally, LFPs from the STN were compared with those in the globus pallidus interna (GPi) from dystonia and PD patients (n=5) and to LFPs in the ventralis intermedius of the thalamus (VIM) in essential tremor patients (n=7). Similar differences were not found in GPi or VIM (p>0.05). Positioning of the electrode in the STN, handedness and side of worse symptoms did not play a significant role.

    Conclusions: Our results highlight differences in STN LFPs during two resting states: eyes open or closed. Understanding changes in brain activity is essential for our development of closed loop systems and interpretation of resting state data.

    Patient Care: This research will have a significant impact on patient care as it defines resting states for activity dependent neurological studies, as well as for the formation of closed loop DBS systems which will optimize deep brain stimulation in the future.

    Learning Objectives: 1. To emphasize the importance of defined resting states when recording LFPs in the STN so that neuronal oscillations may be compared between studies. 2. To compare differences in eyes open or closed in the STN with other brain nuclei in human patients. 3. To discuss how changes in eye open or closed state may effect the development of closed loop DBS systems as well as activity dependent changes in brain activation.

    References: 1. Brown P. Abnormal oscillatory synchronization in the motor system leads to impaired movement. Curr Opin Neurobiol 2007;17:656-664. 2. Marx E, et al. Eyes open and eyes closed as rest conditions: impact on brain activation patterns. Neuroimage 2004;21:1818-1824. 3. Little S, Brown P. The Functional role of beta oscillations in Parkinson’s disease. Parkinsonism and Related Disorders 2014;S44-S48. 4. Hosain MK, Kouzani A, Tye S. Closed Loop Deep Brain Stimulation: an evolving technology. Australas Phys Eng Sci Med 2014 published online DOI 10.1007/s13246-014-0297-2. 5. Priori A, Foffani G, Rossi L, Marceglia S. Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations. Experimental Neurology 2013;245:77-86.

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