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  • Vagal Ganglion Ischemia Induced Lung Edema Leading Decreased Respiration Volume in Subarachnoid Hemorrhage: Experimental Study

    Final Number:

    Mehmet Resid Onen MD; Ilhan Yilmaz MD; Mehmet Dumlu Aydin

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2015 Annual Meeting

    Introduction: It was examined if there is any relationship between vissero sensitive vagal network ischemia and breath disturbances in subarachnoid hemorrhage (SAH).

    Methods: This study was conducted on 21 rabbits. Five animals used control group (GI, n=5), five of used as SHAM group (GII, n=5); and, 11 of them used as study group (GIII, n=11). In the SHAM group was injected with the 1 cc isotonic saline solution, and in the study group was injected with the 1cc autolog blood injecting into cisterna magna. All animals were monitored for detection of heart and breath rhythms in five times/day frequency two weeks. Covered with respiration curves areas were accepted as respiration volume values of animals during experiment course. After the experiment, nodose ganglia of the vagal nerves and alveol volume (AV-mm3) per 1000 mm3 lung tissues of all animals were estimated by Cavalieri methods. In postmortem examination, degenerated neuron neuron density of nodose ganglia (dND) and AVs results were compared statistically

    Results: All data was shown with the table 1. With regard to the respiration parameters and histopathological changes of the vagal nerves observed, degenerated axons were more prominent in animals that developed high frequency tachycardia than those with low frequency tachycardia. Also, animals that displayed respiration irregularity and arrest had more mechanical lesions of nerve roots and degenerated axons in their vagal nerves.

    Conclusions: If vagal nerves are obliged to ischemic degeneration in SAH, the neural reflex network of respiration are paralyzed and respiratory reflexes are disturbed. The ischemic injury cause vagal complex lesion and respiration arrest may be inevitable.

    Patient Care: Treatment of the complications of subaracnoid hemorrhage

    Learning Objectives: in this study, the effects of subaracnoid bleeding on the respiratory system has shown in experimental models.


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