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  • Operative Treatment of Adult Spinal Deformity (ASD) Improves Disease State and Physical Function Regardless of Age and Deformity Type, While Nonoperative Treatment Has No Impact; A 2 Year Prospective

    Final Number:

    J. Scheer; K. Fu; S. Bess; V. Lafage; B. Akbarnia; O. Boachie-Adjei; D. Burton; V. Deviren; R. Hart; M. Gupta; E. Klineberg; T. Errico; G. Mundis; R. Hostin; M. OBrien; K. Kebaish; F. Schwab; C. Shaffrey; J. Smith

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2014 Annual Meeting

    Introduction: Little data exists comparing the impact of operative (OP) and nonoperative (NON) treatment on the disease state for ASD patients. The purpose of the present study was to evaluate OP and NON treatment to restore ASD patients to normative physical function levels and identify disease state correlates for different deformity types using SF-36v2 Health Survey (SF-36) scores.

    Methods: Multicenter, prospective analysis of consecutive ASD patients. Inclusion criteria: no prior spine surgery, age>18years, ASD, and minimum 2yr follow-up. ASD evaluated according to 1) type of scoliosis and 2) severity of sagittal malalignment. Patients divided into OP and NON. Baseline and 2yr SF-36 physical component (PCS) and mental component (MCS) scores were compared to US normative and disease-specific values and reported as norm-based values (NBS) and minimal-clinically-important-difference (MCID).

    Results: 302/497 (61%) patients met inclusion criteria. Baseline PCS for all patients improved (39.8-43.6, 1 MCID) at 2yrs, however values remained <25th percentile for US normative PCS values (45.4). Baseline OP (34.5) PCS was lower than NON (44.6;p<0.05). At 2yrs OP and NON PCS values were similar (43.4vs.43.8; p>0.05). OP improved 3 MCID values (9 NBS points) at 2yrs, whereas NON remained the same. Baseline OP disease state correlates corresponded to one MCID worse than amputee patients (PCS=38.9), which improved to similar PCS disease state values as diabetes (PCS=41.1) and hypertension (PCS=43.96). OP demonstrated PCS improvement of minimum 2 MCID values (6 NBS points; range 6-12; p<0.05) for all deformity types whereas PCS for NON remained the same for all deformity types at 2yrs.

    Conclusions: ASD patients demonstrate severe disability compared to US norms. OP treatment provides improvement for all deformity types whereas NON treatment does not improve disease state regardless of deformity of type. Despite MCID improvement in all deformity types for the OP group, PCS values remain below population norms at 2yr follow up.

    Patient Care: The results of this study will improve patient care by improving patient education and expectations from operative treatment for ASD regarding general health status.

    Learning Objectives: By the conclusion of this session, participants should be able to: 1) appreciate that ASD patients demonstrate severe disability compared to US norms 2) Understand that OP treatment provides improvement whereas NON treatment does not improve disease state regardless of deformity type and 3) that PCS values still remain below population norms despite MCID improvements in the operative group.


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