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  • Considerations about experimental model of intracranial hypertension and evaluation of the microchip system for monitoring of epidural pressure

    Final Number:

    Wellingson S. Paiva MD PhD; Almir F. Andrade MD, PhD; Alessandro Belon BA; Matheus S Soares MD; Marcelo Lima MD; Iuri S Neville MD; Leonardo Moura Sousa Jr MD; Clarissa G Nascimento MD; Jose P Otoch MD; Edson Bor-Seng-Shu MD, PhD; Manoel Jacobsen Teixeira

    Study Design:
    Laboratory Investigation

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2014 Annual Meeting

    Introduction: There are well established method for the measurement with continuous monitoring and treatment of elevated ICP. The method of parenchymal or ventricular monitoring are the most reliable, but they has a higher risk of bleeding and infectious complications. Objectives: In this paper we aim to describe a new experimental animal model of intracranial hypertension and to evaluate the accuracy of the measurement with microchip epidural system

    Methods: 27 pigs with approximately 20 kg were studied, under generaI anesthesia, properly assisted with ventilation and hemodynamic monitoring. During the experiment , we have simulated frontal intracerebral hematoma. We use a multisensor intraparenchymal catheter and a epidural catheter. The experiment consisted of three groups (A, B and C) with intracranial hypertension generated with the simulation of an intracerebral hematoma. In all groups the normal parameters were calibrated: The two systems were compared and studied PIC as the correlation of the measured values.

    Results: The behavior of the ICP over the time points are statistically different between groups (p < 0.001). The simulation ressangramenta resulted in a significant increase in ICP (p < 0.001). Evaluating the overall comparative accuracy there was an intraclass correlation coefficient of 0.8. Using an evaluation of correlation between systems after balloon deflation by means of an analysis of the pressure curve measured by the two methods was observed a failure of correlations. However when evaluated differences in mean pressure at each time of the experiment, we identified a similarity between the systems of monitoring parenchymal and epidural

    Conclusions: The model of intracranial hypertension balloon in pigs is feasible and reliable in generating intracranial hypertension. The system for measuring intracranial epidural pressure has a high correlation coefficient with the system parenchymal gauging the overall evaluation.

    Patient Care: Will be possible to define application of epidural ICP monitor and the clinical conditions in which this system could be used Enhance understanding for the intensive care specialist on acute conditions of intracranial hypertension To describe a reliable experimental model of intracranial hypertension

    Learning Objectives: 1. To define accuracy of epidural intracranial pressure monitoring system 2. To learn about animal model of intracranial pressure 3. To learn about efficacy of clinical and surgical treatment for intracranial hypertension and hemodynamics changes in acute phase of cerebral hematomas

    References: Poca MA, Martínez-Ricarte F, Sahuquillo J, Lastra R, Torné R, Armengol MS. Intracranial pressure monitoring with the Neurodur-P epidural sensor: a prospective study in patients with adult hydrocephalus or idiopathic intracranial hypertension. J Neurosurg. 2008; 108(5):934-42. Poca MA, Sahuquillo J, Topczewski T, Peñarrubia MJ, Muns A. Is intracranial pressure monitoring in the epidural space reliable? Fact and fiction. J Neurosurg. 2007; 106(4):548-56. Raabe A, Totzauer R, Meyer O, Stöckel R, Hohrein D, Schöche J. Reliability of epidural pressure measurement in clinical practice: behavior of three modern sensors during simultaneous ipsilateral intraventricular or intraparenchymal pressure measurement. Neurosurgery. 1998; 43(2):306-11. Raboel PH, Bartek J Jr, Andresen M, Bellander BM, Romner B. Intracranial Pressure Monitoring: Invasive versus Non-Invasive Methods-A Review. Crit Care Res Pract. 2012; 2012:950393.

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