In gratitude of the loyal support of our members, the CNS is offering complimentary 2021 Annual Meeting registration to all members! Learn more.

  • Regular use of aspirin or acetaminophen and risk of brain tumors

    Final Number:
    1461

    Authors:
    Evan Winograd MD; Robert A. Fenstermaker MD; Hakeem Jon Shakir MD

    Study Design:
    Other

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2014 Annual Meeting

    Introduction: Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of cancer, although few studies have examined associations with brain tumor risk.

    Methods: The current study investigated the effects of regular aspirin or acetaminophen use on brain tumor risk among 176 individuals with primary, incident brain tumors and 704 age and sex matched hospital controls with non-neoplastic conditions who completed a comprehensive epidemiologic questionnaire.

    Results: Results indicate that regular aspirin use may be associated with decreased brain tumor risk among men [adjusted odds ratio (aOR) 0.63, 95% confidence interval (CI) 0.40–1.01], but not among women (aOR 1.13, 95% CI 0.65–1.95). Similarly, regular acetaminophen use may have been associated with decreased risk among men (aOR 0.58, 95% CI 0.26-1.29), with the most pronounced effect noted for men who had used acetaminophen regularly for more than 10 years (aOR 0.10, 95% CI 0.01-0.79).

    Conclusions: Based on these results, Aspirin may have a chemoprotective or anti-gliomagenesis effect with regard to brain tumors, indicating the need for further investigation in both basic sciences and larger clinical studies.

    Patient Care: With the proposed inverse relationship between NSAIDs and glioblastoma in this patient population, this may be an additive to current therapeutic measures, or may in the future be used as a preventive measure in patients with strong family histories of glioblastoma or glioma in general.

    Learning Objectives: Based on this session, participants should be aware of the possibility that basic medications such as NSAIDs, specifically aspirin, have a potential anti-gliomagenesis effect.

    References: 1. Kyritsis AP, Saya H: Epidemiology, cytogenetics, and molecular biology of brain tumors. Curr Opin Oncol 5:474-480, 1993 2. McKinley B, Michalek AM, Fenstermaker RA, Plunkett RJ: The impact of age and sex on the incidence of glial tumors in New York State from 1976 to 1995. J Neurosurg, 93(6):932-939, 2000. 3. Kuratsu J, Ushio Y: Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto Prefecture in the southern part of Japan. J Neurosurg 84:946-950, 1996. 4. Inskip PD, Linet MS, Heineman EF: Etiology of brain tumors in adults. Epidemiol Rev 17:382-414, 1995. 5. Fleury A, Menegoz F, Grosclaude P, et al: Descriptive epidemiology of cerebral gliomas in France. Cancer 79:1195-1202, 1997. 6. Walker AE, Robins M, Weinfeld FD: Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 35:219-226, 1985. 7. Wrensch M, Bondy ML, Weincke J, et al: Environmental risk factors for primary malignant brain tumors: a review. J Neuro-Oncology 17:47-64, 1993. 8. Lee WJ, Colt JS, Heineman EF, McComb R, Weisenburger DD, Lijinsky W, Ward MH. Agricultural pesticide use and risk of glioma in Nebraska, United States. Occup Environ Med. 62:786-92, 2005. 9. Andersson E, Nilsson R, Toren K. Gliomas among men employed in the Swedish pulp and paper industry. Scand J Work Environ Health. 28:333-40, 2002. 10. McLaughlin JK, Malker HS, Blot WJ, Malker BK, Stone BJ, Weiner JA, Ericsson JL, Fraumeni JF Jr. Occupational risks for intracranial gliomas in Sweden. J Natl Cancer Inst. 78(2):253-7, 1987. 11. Thomas TL, Stewart PA, Stemhagen A, Correa P, Norman SA, Bleecker ML, Hoover RN. Risk of astrocytic brain tumors associated with occupational chemical exposures. A case-referent study. Scand J Work Environ Health. 13:417-23, 1987. 12. Kaplan S, Novikov I, Modan B. Nutritional factors in the etiology of brain tumors: potential role of nitrosamines, fat, and cholesterol. Am J Epidemiol. 15;146(10):832-41, 1997. 13. Giles GG, McNeil JJ, Donnan G, Webley C, Staples MP, Ireland PD, Hurley SF, Salzberg M. Dietary factors and the risk of glioma in adults: results of a case-control study in Melbourne, Australia. Int J Cancer. 1;59(3):357-62, 1994. 14. Tedeschi-Blok N, Lee M, Sison JD, Miike R, Wrensch M. Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study. BMC Cancer. 3;6:148, 2006. 15. Holick CN, Giovannucci EL, Rosner B, Stampfer MJ, Michaud DS. Prospective study of cigarette smoking and adult glioma: Dosage, duration, and latency. Neuro-oncol. 2007 May 15; [Epub ahead of print] 16. Neglia JP, Robison LL, Stovall M, Liu Y, Packer RJ, Hammond S, Yasui Y, Kasper CE, Mertens AC, Donaldson SS, Meadows AT, Inskip PD. New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 1;98(21):1528-37, 2006. 17. Oldendorf WH. Brain uptake of metabolites and drugs following carotid arterial injections. Trans Am Neurol Assoc. 96:46-50, 1971.

We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy