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  • Low-Grade Gliomas in Older Patients: Do Mutations Drive Outcomes?

    Final Number:

    Pamela Stuart Jones MD; Matthew Koch MD; Matthew Frosch; Daniel P. Cahill MD; William T. Curry MD

    Study Design:

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2014 Annual Meeting

    Introduction: Despite growing knowledge about the molecular genetics and prognosis of low-grade gliomas, management strategy for these lesions remains unclear, especially in older patients. Determining optimal treatment for patients 50 and older is difficult given the relative rarity of these lesions and limited of information on IDH1 mutation status in this population.

    Methods: We reviewed the records of patients age > 50 years with pathologically confirmed WHO grade II gliomas treated at Massachusetts General Hospital between 1995 and 2013.

    Results: Median survival for the entire group (N = 43, median age 56 years, range 50 to 77 years) was 11.3 years with 5- and 10-year survival rates of 74.8% and 56.3%, respectively. On direct comparison, patients with oligodendrogliomas had significantly higher overall survival than patients with astrocytomas, with five-year and ten-year survivals of 87.1% v. 63.6%, and 78.4% v. 31.8% (p=0.04). Median overall survival for patients with astrocytomas was 7.6 years, whereas median overall survival for patients with oligodendrogliomas had not yet been reached at time of data collection. For patients with IDH1 mutations (n=14), overall survival was increased compared to patients without the mutation (n=17). Five-year and 10-year overall survivals were 77.8% and 77.8% for IDH1-mutant patients and were 59.1% and 29.6%, respectively, for IDH1-wildtype patients (p=0.06). Younger age at diagnosis (p=0.0019, Hazard Ratio (HR)=1.18), tumors amenable to resection beyond biopsy (p=0.0055, HR=0.073), and oligodendroglioma pathology (p=0.022, HR=0.179) were associated with significantly longer median survival on multivariate analysis.

    Conclusions: Similar to younger populations, oligodendroglioma pathology and any tumor resection beyond biopsy offers improved survival in older patients with low-grade glioma. IDH-1 mutation is less common than in younger patients, but is associated with improved overall survival. Further studies are needed to clarify optimal treatment strategy for elderly patients with low-grade gliomas and known IDH genotype.

    Patient Care: This research is a start to investigating the best treatment for elderly patients with low-grade gliomas based on their IDH1 mutation status. It is likely that there may be two different strategies for care based on their molecular genotype.

    Learning Objectives: By the conclusion of this session, participants should be able to 1) describe the importance of IDH1 mutation in survival for low-grade gliomas 2) discuss, in small groups, the treatment strategies for for low-grade gliomas in elderly patients and 3) identify


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