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  • Results of Transsphenoidal Surgery in Outcome of Cushing's Disease

    Final Number:

    Manochehr Shirvani MD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2013 Annual Meeting

    Introduction: To analyze the therapeutic results of TSS in patients with Cushing's disease and their outcome

    Methods: Patients diagnosed as Cushing's disease and referred for surgery to our tertiary care center from Mar 1998 to Jan 2011 were retrospectively analyzed

    Results: 101 patients were treated by TSS during this period by a single surgeon, 91 of them had good length of follow up (mean 3 ± 3.2 y). 84 (92%) had remission after surgery, 19 (22%) of them developed recurrence of their disease that most of them were children and young adults (only 4 aged more than 30 years old). Review of postoperative cortisol in recurrent cases revealed values less than 5 mic/dL in only 5 patients. Preoperative tumor size was not a factor in relapse of the disease and only one of 19 cases had macroadenoma in preoperative imaging.

    Conclusions: TSS is the preferred modality of treatment in Cushing's disease but long term follow up is necessary for detection of relapses

    Patient Care: By insisting in long term follow up of Cushing's disease cases after pituitary surgery

    Learning Objectives: By the conclusion of this session, participants should be able to describe the importance of follow up after TSS in Cushing's disease


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