Introduction: Intracranial hemangiopericytoma is a rare tumor and population-based survival and prognostic studies are lacking. The goal of this study was to describe survival rates and identify prognostic factors associated with survival in patients with hemangiopericytoma using a 30-year US national cancer registry (Surveillance, Epidemiology, and End Results [SEER]).
Methods: Patients with intracranial hemangiopericytoma were queried in the SEER registry (1973–2005) based on International Classification of Disease for Oncology, Third Edition coding. Estimated Kaplan-Meier survival curves were constructed for surgery type, extent of invasion, and radiation treatment; Log-rank and Wilcoxon tests were used to assess the correlation. Proportional hazards regression analysis was used to evaluate the association between age, year of diagnosis, and survival time.
Results: A total 147 patients with intracranial hemangiopericytoma were identified in SEER. The overall median survival was 9.9 years, with 1-year, 5-year, and 10-year survival rates of 93%, 74%, and 46%, respectively. Surgical resection was carried out in 84% and Radiation was administered to 57% of patients as part of initial treatment. Of the 117 patients with available extent of resection data, 65 (56%) underwent a gross-total resection, 29 (25%) – a subtotal resection, and 23 (20%) had a biopsy. Patients treated with gross-total resection had a median survival of 9.2 years compared to 7.1 years among those treated with subtotal resection. Of the 80 patients with extent of invasion data, 5 patients (6%) who developed extracranial metastasis had a median survival of 3 years. Increasing age in decades and earlier year of surgery were associated with decreased survival (hazard ratios: 1.29, 0.69; p-values of 0.0029 and 0.0741, respectively).
Conclusions: Majority of patients with hemangiopericytoma are being treated with surgery and radiation as part of their initial treatment. Age and the presence of distal metastases are significant prognostic factors for survival in hemangiopericytoma.
Patient Care: This research will allow practitioners to accurately assess the prognosis of patients with hemangiopericytoma and identify treatments that improve outcomes.
Learning Objectives: By the conclusion of the this session participants should be able to 1) describe survival rates 2) identify prognostic factors associated with survival in patients with hemangioparacytoma.