Skip to main content
  • Microsurgical Management of Intracranial Aneurysms: Review of Intraoperative Monitoring Techniques and Outcomes

    Final Number:
    1301

    Authors:
    pinjing hui; Shiming Zhang; Qing Lan MD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2012 Annual Meeting

    Introduction: The outcome of surgical treatment of cerebral aneurysms may be severely impaired by local ischaemia, or by infarction resulting from the inadvertent occlusion or stenosis of a parent vessel or its distal branches. Incomplete aneurym occlusion, on the other hand, increases the risk of haemorrhage. Despite great attempts to preserve patency at the time of clip application, intraoperative visual observation may not reveal arterial compromise or occlusion. It is therefore of the utmost importance that both aneurysm occlusion and inadvertent clipping of neighbouring vessels be avoided during the surgical act.

    Methods: This article has two major aims: to review the cerebral hemodynamic changes with aneurysms, and to indicate and compare intraoperative monitoring techniques:intraoperative angiography(IOA),indocyanine green angiography (ICG),intraoperative microvascular Doppler(IMD) during cerebral aneurysm surgery.

    Results: The time taken for an IOA in aneurysm surgery varied from 30 min to 45 min.IOA carries the risk of arterial injury or stroke and its widespread availability is limited.In patients with large or giant, wide-neck aneurysms or with thick-walled atherosclerotic vessels, the ICG may be unreliable. In many patients, the availability of this tool has obviated the need for intraoperative catheter-based angiography, but a limitation of ICG is that it is only useful in the assessment of brain vessels along the line of sight of the microscope. The Doppler microprobe was placed with an insonation angle of 30–60 degrees. The mean duration of IMD investigations was 5.3 minutes. There were no complications of intraoperative microvascular Doppler probe use.

    Conclusions: After placement of the permanent clip on the aneurysmal neck, non-invasive IMD, ICG,or invasive IOA are employed to assess the patency of the parent artery as well as the entire occlusion of the aneurysm neck.It is recommended that IMD be used routinely in cerebral aneurysm surgery, especially in those large and giant aneurysms with wide neck or without neck.

    Patient Care: It is recommended that IMD be used routinely in cerebral aneurysm surgery, especially in those large and giant aneurysms with wide neck or without neck. This technique is a valuable tool, instead of intraoperative angiography for the surgical treatment of aneurysms.

    Learning Objectives: Qualitative analysis and quantitative analysis measurement of blood flow in cerebral vessels during aneurysm surgery can help prevent ischaemia and improve patient outcome. The present study was performed to investigate the reliability and practicability of intraoperative monitoring techniques during cerebral aneurysm surgery, and to assess the influence of this method on the surgical procedure.

    References: 1. Wu TC, Tsui YK, Chen TY, Lin CJ, Wu TC, Tzeng WS. Rebleeding of aneurysmal subarachnoid hemorrhage in computed tomography angiography: risk factor, rebleeding pattern, and outcome analysis. J Comput Assist Tomogr 2012;36(1):103-108. [PubMed: 22261779] 2. Schichor C, Rachinger W, Morhard D, et al. Intraoperative computed tomography angiography with computed tomography perfusion imaging in vascular neurosurgery: feasibility of a new concept. J Neurosurg 2010;112(4):722-728. [PubMed: 19817544] 3. Meng H, Wang Z, Hoi Y, et al. Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke 2007;38(6):1924-1931. [PubMed: 17495215 ] 4. Yurt A, Vardar E, Selçuki M, Ertürk AR, Ozbek G, Atçi B. Biomarkers of connective tissue disease in patients with intracranial aneurysms. J Clin Neurosci 2010;17(9):1119-1121. [PubMed: 20452221 ] 5. Shojima M, Oshima M, Takagi K, et al. Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke 2004;35(11):2500-2505. [PubMed: 15514200 ] 6. Swietaszczyk C, Maciaczyk J, Tafil-Klawe M, Kasprzak HA. What is the origin of cerebral aneurysms? Przegl Lek 2004;61(2):115-119. [PubMed: 15230154] 7. Seibert B, Tummala RP, Chow R, Faridar A, Mousavi SA, Divani AA. Intracranial aneurysms: review of current treatment options and outcomes. Front Neurol 2011;2:45. [PubMed: 21779274] 8. Winn HR, Jane JA Sr, Taylor J, Kaiser D, Britz GW. Prevalence of asymptomatic incidental aneurysms: review of 4568 arteriograms. J Neurosurg 2002;96(1):43-49. [PubMed: 11794602] 9. Rojas Jiménez A, Martínez Cueto P, Vila Nieto O, Vázquez Fernández E. Incidental aneurysms and perimesencephalic subarachnoid haemorrhages. Radiologia 2011; 22. [PubMed: 21944713 ] 10. Bonneville F, Sourour N, Biondi A. Intracranial aneurysms: an overview. Neuroimaging Clin N Am 2006;16(3):371-382. [PubMed: 16935705 ] 11. Qureshi AI, Vazquez G, Tariq N, Suri MF, Lakshminarayan K, Lanzino G. Impact of International Subarachnoid Aneurysm Trial results on treatment of ruptured intracranial aneurysms in the United States. J Neurosurg 2011;114(3):834-841. [PubMed: 20653392 ] 12. Bakker NA, Metzemaekers JD, Groen RJ, Mooij JJ, Van Dijk JM. International subarachnoid aneurysm trial 2009: endovascular coiling of ruptured intracranial aneurysms has no significant advantage over neurosurgical clipping. Neurosurgery 2010;66:961-962. [PubMed: 20404700] 13. Raper DM, Allan R. International subarachnoid trial in the long run: critical evaluation of the long-term follow-up data from the ISAT trial of clipping vs coiling for ruptured intracranial aneurysms. Neurosurgery 2010;66:1166-1169. [PubMed: 20421838] 14. Chicoine MR. Microsurgery and clipping: the gold standard for the treatment of intracranial aneurysms. J Neurosurg Anesthesiol 2003;15(1):61-63. [PubMed: 12499987] 15. Takao H, Nojo T.Treatment of unruptured intracranial aneurysms: decision and cost-effectiveness analysis. Radiology 2007;244(3):755-766. [PubMed: 17652191 ] 16. Fagundes-Pereyra WJ, Hoffman WE, Misra M, Charbel FT. Clip readjustment in aneurysm surgery after flow evaluation using the ultrasonic perivascular probe: case report. Arq Neuropsiquiatr 2005;63(2A):339-344. [PubMed: 16100988] 17. Hauck EF, Wohlfeld B, Welch BG, White JA, Samson D. Clipping of very large or giant unruptured intracranial aneurysms in the anterior circulation: an outcome study. J Neurosurg 2008;109:1012-1018. [PubMed: 19035713] 18. Friedman JA, Kumar R. Intraoperative angiography should be standard in cerebral aneurysm surgery. BMC Surg 2009;9:7. [PubMed: 19405979] 19. Petridis AK, Doukas A, Niu H, et al. Three dimensional rotational angiography in surgical planning of aneurysm clipping. Vasa 2011;40(5):375-380. [PubMed: 21948780] 20. Dehdashti AR, Thines L, Da Costa LB, et al. Intraoperative biplanar rotational angiography during neurovascular surgery. Technical note. J Neurosurg 2009;111(1):188-192. [PubMed: 19301971] 21. Pai BS, Muralimohan S. Intraoperative angiography in aneurysm surgery: an initial experience. Neurol India 2010;58(4):571-575. [PubMed: 20739794] 22. Katz JM, Gologorsky Y, Tsiouris AJ, et al. Is routine intraoperative angiography in the surgical treatment of cerebral aneurysms justified? A consecutive series of 147 aneurysms. Neurosurgery 2006;58(4):719-727. [PubMed: 16575336] 23. Klopfenstein JD, Spetzler RF, Kim LJ, et al. Comparison of routine and selective use of intraoperative angiography during aneurysm surgery: a prospective assessment. J Neurosurg 2004;100(2):230-235. [PubMed: 15086229] 24. Liu DZ, Mathes DW, Zenn MR, Neligan PC. The application of indocyanine green fluorescence angiography in plastic surgery. J Reconstr Microsurg 2011;27(6):355-364. [PubMed: 21717392] 25. Suzuki K, Kodama N, Sasaki T, et al. Confirmation of blood flow in perforating arteries using fluorescein angiography during aneurysm surgery. J Neurosurg 2007;107:68-73. [PubMed: 17639876] 26. Hänggi D, Etminan N, Steiger HJ. The impact of microscope-integrated intraoperative near-infrared indocyanine green videoangiography on surgery of arteriovenous malformations and dural arteriovenous fistulae. Neurosurgery 2010;67(4):1094-1103. [PubMed: 20881574] 27. Wang S, Liu L, Zhao YL, Zhang D, Yang MQ, Zhao JZ. Effects of surgical microscope-based indocyanine green videoangiography during aneurysm surgery. Zhonghua Yi Xue Za Zhi 2009;89:146-150. [PubMed: 19537026] 28. Mery FJ, Amin-Hanjani S, Charbel FT. Is an angiographically obliterated aneurysm always secure? Neurosurgery 2008;62(4):979-982. [PubMed: 18496204] 29. Dashti R, Laakso A, Niemelä M, Porras M, Hernesniemi J. Microscope-integrated near-infrared indocyanine green videoangiography during surgery of intracranial aneurysms: the Helsinki experience. Surg Neurol 2009;71(5):543-550. [PubMed: 19328531] 30. Imizu S, Kato Y, Sangli A, Oguri D, Sano H. Assessment of incomplete clipping of aneurysms intraoperatively by a near-infrared indocyanine green-video angiography (Niicg-Va) integrated microscope. Minim Invasive Neurosurg 2008;51(4):199-203. [PubMed: 18683109] 31. Dashti R, Laakso A, Niemelä M, et al. Application of microscope integrated indocyanine green video-angiography during microneurosurgical treatment of intracranial aneurysms: a review. Acta Neurochir Suppl 2010;107:107-109. [PubMed: 19953380] 32. Oda J, Kato Y, Chen SF, et al. Intraoperative near-infrared indocyanine green-videoangiography (ICG-VA) and graphic analysis of fluorescence intensity in cerebral aneurysm surgery. J Clin Neurosci 2011;18(8):1097-1100. [PubMed: 21715173] 33. Raabe A, Nakaji P, Beck J, et al. Prospective evaluation of surgical microscope-integrated intraoperative near-infrared indocyanine green videoangiography during aneurysm surgery. J Neurosurg 2005;103(6):982-989. [PubMed: 16381184] 34. Wang S, Liu L, Zhao Y, Zhang D, Yang M, Zhao J. Evaluation of surgical microscope-integrated intraoperative near-infrared indocyanine green videoangiography during aneurysm surgery. Neurosurg Rev 2010;34(2):209-215. [PubMed: 21301915] 35. Holm C, Mayr M, Höfter E, Dornseifer U, Ninkovic M. Assessment of the patency of microvascular anastomoses using microscope-integrated near-infrared angiography: a preliminary study. Microsurgery 2009;29(7):509-514. [PubMed: 19306390] 36. Li J, Lan Z, He M, You C. Assessment of microscope-integrated indocyanine green angiography during intracranial aneurysm surgery: a retrospective study of 120 patients. Neurol India 2009;57(4):453-459. [PubMed: 19770547] 37. Kirk HJ, Rao PJ, Seow K, Fuller J, Chandran N, Khurana VG. Intra-operative transit time flowmetry reduces the risk of ischemic neurological deficits in neurosurgery. Br J Neurosurg 2009;23(1):40-47. [PubMed: 19234908] 38. Hui PJ, Zhang SM, Liu M, et al. Application of intraoperative microvascular Doppler uhrasonography in cerebral aneurysm surgery. Chin J Neurosurg 2007;23(11):804-807. 39. Hui PJ, Zhang SM, Wang Z, et al. Microvascular Doppler ultrasonography in internal carotid artery aneurysms surgery. Chin J Neurosurg 2010;26:874-876. 40. Marchese E, Albanese A, Denaro L, Vignati A, Fernandez E, Maira G. Intraoperative microvascular Doppler in intracranial aneurysm surgery. Surg Neurol 2005;63(4):336-342. [PubMed: 15808715] 41. Mücke T, Wolff KD, Wagenpfeil S, Hölzle F, Scholz M. Reliability of near-infrared angiography and micro-Doppler sonography for evaluating microvascular anastomoses. Plast Reconstr Surg 2010;126(5):1506-1514. [PubMed: 21042107] 42. Akdemir H, Oktem IS, Tucer B, Menkü A, Basaslan K, Günaldi O. Intraoperative microvascular Doppler sonography in aneurysm surgery. Minim Invasive Neurosurg 2006;49(5):312-316. [PubMed: 17163348] 43. Fagundes-Pereyra WJ, Hoffman WE, Misra M, Charbel FT. Clip readjustment in aneurysm surgery after flow evaluation using the ultrasonic perivascular probe: case report. Arq Neuropsiquiatr 2005;63(2A):339-344. [PubMed: 16100988] 44. Amin-Hanjani S, Meglio G, Gatto R, Bauer A, Charbel FT. The utility of intraoperative blood flow measurement during aneurysm surgery using an ultrasonic perivascular flow probe. Neurosurgery 2008;62(6 Suppl 3):1346-1353. [PubMed: 18695554] 45. Amin-Hanjani S, Charbel FT. Flow-assisted surgical technique in cerebrovascular surgery. Surg Neurol 2007;68 Suppl 1:S4-11. [PubMed: 17963920] 46. Carter BS, Farrell C, Owen C. Microsurgical clip obliteration of middle cerebral aneurysm using intraoperative flow assessment. J Vis Exp 2009; 25;(31). pii: 1294. [PubMed: 19783972] 47. Cui H, Wang Y, Yin Y, et al. Role of intraoperative microvascular Doppler in the microsurgical management of intracranial aneurysms. J Clin Ultrasound 2011;39(1):27-31. [PubMed: 20949570] 48. Xu BN, Sun ZH, Romani R, et al. Microsurgical management of large and giant paraclinoid aneurysms. World Neurosurg 2010;73(3):137-146. [PubMed: 20860951] 49. Gruber A, Dorfer C, Standhardt H, Bavinzski G, Knosp E. Prospective comparison of intraoperative vascular monitoring technologies during cerebral aneurysm surgery. Neurosurgery 2011;68(3):657-673. [PubMed: 21164372]

We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy